| Literature DB >> 19847800 |
Cristina Lo Celso1, Juwell W Wu, Charles P Lin.
Abstract
In this review we provide a description of the basic concepts and paradigms currently constituting the foundations of adult stem cell biology, and discuss the role that live imaging techniques have in the development of the field. We focus on live imaging of hematopoietic stem cells (HSCs) as the basic biology and clinical applications of HSCs have historically been at the forefront of the stem cell field, and HSC are the first mammalian tissue stem cells to be visualized in vivo using advanced light microscopy techniques. We outline the current technical challenges that remain to be overcome before stem cells and their niche can be more fully characterized using the live imaging technology. (c) 2009 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimEntities:
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Year: 2009 PMID: 19847800 DOI: 10.1002/jbio.200910072
Source DB: PubMed Journal: J Biophotonics ISSN: 1864-063X Impact factor: 3.207