Carlos A Rubio1, Marjo Kapraali, Ragnar Befrits. 1. Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden. Carlos.Rubio@ki.se
Abstract
BACKGROUND: The frequency of colorectal carcinomas (CRC) evolving in patients with Crohn's colitis (CC) was assessed at the Danderyds University Hospital (DUH), one of two large hospitals in Northwest Stockholm County (NWSC). PATIENTS AND METHODS: A total of 121 patients with Crohn's disease (CD) were treated at this hospital between 1996 and 2006. All sections from colectomy specimens having CC and carcinoma were reviewed. RESULTS: Of the 121 patients with CD, 79.4% (96/121) had CC. Of the 96 patients with CC, 6.3% (n=6) developed a CRC between 1996 and 2006. DISCUSSION: Recent studies at the other large hospital in NWSC showed that during the same period (1996-2006) 7.4% (n=21) of the 282 patients with CC, developed a CRC. During this 11-year period, 7.1% (n=27) of the 378 patients with CC seen at the two hospitals that treat the vast majority of patients with CD in NWSC developed a CRC. By comparison, only 0.29% or 5,566 patients (age-adjusted) out of the 1,900,000 inhabitants in the entire Stockholm County developed a CRC during the same period. These results, obtained at a comparative time-interval in the County, substantiate several recent meta-analysis and population-based studies on the high cancer risk in patients with Crohn disease.
BACKGROUND: The frequency of colorectal carcinomas (CRC) evolving in patients with Crohn's colitis (CC) was assessed at the Danderyds University Hospital (DUH), one of two large hospitals in Northwest Stockholm County (NWSC). PATIENTS AND METHODS: A total of 121 patients with Crohn's disease (CD) were treated at this hospital between 1996 and 2006. All sections from colectomy specimens having CC and carcinoma were reviewed. RESULTS: Of the 121 patients with CD, 79.4% (96/121) had CC. Of the 96 patients with CC, 6.3% (n=6) developed a CRC between 1996 and 2006. DISCUSSION: Recent studies at the other large hospital in NWSC showed that during the same period (1996-2006) 7.4% (n=21) of the 282 patients with CC, developed a CRC. During this 11-year period, 7.1% (n=27) of the 378 patients with CC seen at the two hospitals that treat the vast majority of patients with CD in NWSC developed a CRC. By comparison, only 0.29% or 5,566 patients (age-adjusted) out of the 1,900,000 inhabitants in the entire Stockholm County developed a CRC during the same period. These results, obtained at a comparative time-interval in the County, substantiate several recent meta-analysis and population-based studies on the high cancer risk in patients with Crohn disease.
Authors: Cord Langner; Fernando Magro; Ann Driessen; Arzu Ensari; Gerassimos J Mantzaris; Vincenzo Villanacci; Gabriel Becheanu; Paula Borralho Nunes; Gieri Cathomas; Walter Fries; Anne Jouret-Mourin; Claudia Mescoli; Giovanni de Petris; Carlos A Rubio; Neil A Shepherd; Michael Vieth; Rami Eliakim; Karel Geboes Journal: Virchows Arch Date: 2014-02-01 Impact factor: 4.064