CONTEXT: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. PATIENTS AND METHODS: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA. RESULTS: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression analyses showed that a higher serum IGF-I concentration was associated with a significantly reduced risk of having a leukocyte telomere length in the lowest tertile group and also after adjustment for multiple covariates (P < 0.01). Multivariate linear regression analyses demonstrated that tertile of leukocyte telomere length was positively, whereas age was negatively, associated with serum IGF-I concentration in elderly men. CONCLUSIONS: In this large population-based, cross-sectional study, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men. The mechanisms underlying the association between serum IGF-I concentration and leukocyte telomere length remain to be determined.
CONTEXT: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. PATIENTS AND METHODS: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA. RESULTS: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression analyses showed that a higher serum IGF-I concentration was associated with a significantly reduced risk of having a leukocyte telomere length in the lowest tertile group and also after adjustment for multiple covariates (P < 0.01). Multivariate linear regression analyses demonstrated that tertile of leukocyte telomere length was positively, whereas age was negatively, associated with serum IGF-I concentration in elderly men. CONCLUSIONS: In this large population-based, cross-sectional study, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men. The mechanisms underlying the association between serum IGF-I concentration and leukocyte telomere length remain to be determined.
Authors: Zbigniew Darzynkiewicz; Hong Zhao; H Dorota Halicka; Jiangwei Li; Yong-Syu Lee; Tze-Chen Hsieh; Joseph M Wu Journal: Cytometry A Date: 2014-02-22 Impact factor: 4.355
Authors: J A Batsis; T A Mackenzie; E Vasquez; C M Germain; R T Emeny; P Rippberger; F Lopez-Jimenez; S J Bartels Journal: Int J Obes (Lond) Date: 2017-08-16 Impact factor: 5.095
Authors: W Chen; M Kimura; S Kim; X Cao; S R Srinivasan; G S Berenson; J D Kark; A Aviv Journal: J Gerontol A Biol Sci Med Sci Date: 2011-02-10 Impact factor: 6.053
Authors: Karl-Heinz Ladwig; Anne Catharina Brockhaus; Jens Baumert; Karoline Lukaschek; Rebecca T Emeny; Johannes Kruse; Veryan Codd; Sibylle Häfner; Eva Albrecht; Thomas Illig; Nilesh J Samani; H Erich Wichmann; Christian Gieger; Annette Peters Journal: PLoS One Date: 2013-07-03 Impact factor: 3.240