Literature DB >> 19846238

Application of Huisgen (3+2) cycloaddition reaction: synthesis of 1-(2,3-dihydrobenzofuran-2-yl-methyl [1,2,3]-triazoles and their antitubercular evaluations.

Rama P Tripathi1, Amit Kumar Yadav, Arya Ajay, Surendra Singh Bisht, Vinita Chaturvedi, Sudhir Kumar Sinha.   

Abstract

1,4-Disubstituted-1,2,3-triazoles (3-27) have been synthesized by [3+2] cycloaddition of different 2-(azidomethyl)-dihydronaptho(benzo)furans (2a, 2b, 2c and 2d) with different alkynes. All the compounds were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv. Compounds 2a, 7, 9, 12 and 14 exhibited antitubercular activities with MIC ranging from 12.5 to 3.12 microg/ml. Copyright 2009 Elsevier Masson SAS. All rights reserved.

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Year:  2009        PMID： 19846238     DOI： 10.1016/j.ejmech.2009.09.036

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  11 in total

1.  Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR.

Authors:  Lili Ou; Shuang Han; Wenbo Ding; Ping Jia; Bo Yang; Jose L Medina-Franco; Marc A Giulianotti; Jian-Zhong Chen; Yongping Yu
Journal:  Mol Divers       Date:  2011-07-10       Impact factor: 2.943

2.  Catalytic stereoselective synthesis of diverse oxindoles and spirooxindoles from isatins.

Authors:  Jacob P MacDonald; Joseph J Badillo; Gary E Arevalo; Abel Silva-García; Annaliese K Franz
Journal:  ACS Comb Sci       Date:  2012-04-02       Impact factor: 3.784

3.  Design, synthesis, anticancer activity and docking studies of theophylline containing 1,2,3-triazoles with variant amide derivatives.

Authors:  Radhakrishnam Raju Ruddarraju; Adharvana Chari Murugulla; Ravindar Kotla; Muni Chandra Babu Tirumalasetty; Rajendra Wudayagiri; Shobha Donthabakthuni; Ravichandar Maroju
Journal:  Medchemcomm       Date:  2016-10-28       Impact factor: 3.597

4.  Quantum Computational Investigation of (E)-1-(4-methoxyphenyl)-5-methyl-N'-(3-phenoxybenzylidene)-1H-1,2,3-triazole-4-carbohydrazide.

Authors:  Halil Gökce; Fatih Şen; Yusuf Sert; Bakr F Abdel-Wahab; Benson M Kariuki; Gamal A El-Hiti
Journal:  Molecules       Date:  2022-03-28       Impact factor: 4.411

5.  Synthesis and antioxidant evaluation of enantiomerically pure bis-(1,2,3-triazolylmethyl)amino esters from modified α-amino acids.

Authors:  Juan I Sarmiento-Sánchez; Adrián Ochoa-Terán; Ignacio A Rivero
Journal:  ScientificWorldJournal       Date:  2014-10-15

6.  Structurally Divergent Lithium Catalyzed Friedel-Crafts Reactions on Oxetan-3-ols: Synthesis of 3,3-Diaryloxetanes and 2,3-Dihydrobenzofurans.

Authors:  Rosemary A Croft; James J Mousseau; Chulho Choi; James A Bull
Journal:  Chemistry       Date:  2016-10-10       Impact factor: 5.236

Review 7.  Recent Advances in Phthalan and Coumaran Chemistry.

Authors:  Efimov Ilya; Larisa Kulikova; Erik V Van der Eycken; Leonid Voskressensky
Journal:  ChemistryOpen       Date:  2018-11-23       Impact factor: 2.911

8.  Quinoline-triazole hybrids inhibit falcipain-2 and arrest the development of Plasmodium falciparum at the trophozoite stage.

Authors:  Anju Singh; Md Kalamuddin; Asif Mohmmed; Pawan Malhotra; Nasimul Hoda
Journal:  RSC Adv       Date:  2019-11-29       Impact factor: 3.361

Review 9.  Dihydronaphthofurans: synthetic strategies and applications.

Authors:  Abolfazl Olyaei; Mahdieh Sadeghpour
Journal:  RSC Adv       Date:  2020-02-05       Impact factor: 4.036

10.  Synthesis, Antimicrobial and cytotoxic activity of New Heterocyclic Hybrids Based on 2,5-Dimethylpyrrole and Pyrrole Scaffolds.

Authors:  S D Joshi; U A More; V H Kulkarni
Journal:  Indian J Pharm Sci       Date:  2013-05       Impact factor: 0.975
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