PURPOSE: We provide an overview of basic, clinical and epidemiological research in the field of erectile dysfunction and important research priorities presented at the 2009 National Institute of Diabetes and Digestive and Kidney Diseases symposium on Urological Complications of Diabetes and Obesity. MATERIALS AND METHODS: Experts in molecular biology, physiology, pharmacology, clinical trials, epidemiology and urological surgery highlighted current knowledge on erectile dysfunction associated with diabetes mellitus and obesity. RESULTS: Predictable associations between erectile dysfunction, and poor diabetic control and modifiable risk factors, including body mass index, have not yet been translated into randomized trials in the United States. The relationship between erectile dysfunction and metabolic syndrome, and surrogate markers for erectile dysfunction requires further investigation. Basic research aimed at discovering disease mechanisms and therapeutic targets has focused on autonomic neuropathy, vascular dysfunction, smooth muscle contractile function and matrix. However, significant gaps exist in regard to the integration of molecular, cellular and functional data. Animal models of type 2 diabetes and obesity associated erectile dysfunction require investigation because most basic science studies have used rodent models of type 1 diabetes. CONCLUSIONS: Studies are needed to synthesize a systems biology understanding of erectile function/dysfunction, and characterize and disseminate rodent models of erectile dysfunction associated with type 2 diabetes and obesity. Clinical studies are needed of promising intervention and prevention strategies. Leveraging existing and future cohort phenotypes, and biological samples is needed for risk factor analysis, biomarker discovery and genome wide association studies.
PURPOSE: We provide an overview of basic, clinical and epidemiological research in the field of erectile dysfunction and important research priorities presented at the 2009 National Institute of Diabetes and Digestive and Kidney Diseases symposium on Urological Complications of Diabetes and Obesity. MATERIALS AND METHODS: Experts in molecular biology, physiology, pharmacology, clinical trials, epidemiology and urological surgery highlighted current knowledge on erectile dysfunction associated with diabetes mellitus and obesity. RESULTS: Predictable associations between erectile dysfunction, and poor diabetic control and modifiable risk factors, including body mass index, have not yet been translated into randomized trials in the United States. The relationship between erectile dysfunction and metabolic syndrome, and surrogate markers for erectile dysfunction requires further investigation. Basic research aimed at discovering disease mechanisms and therapeutic targets has focused on autonomic neuropathy, vascular dysfunction, smooth muscle contractile function and matrix. However, significant gaps exist in regard to the integration of molecular, cellular and functional data. Animal models of type 2 diabetes and obesity associated erectile dysfunction require investigation because most basic science studies have used rodent models of type 1 diabetes. CONCLUSIONS: Studies are needed to synthesize a systems biology understanding of erectile function/dysfunction, and characterize and disseminate rodent models of erectile dysfunction associated with type 2 diabetes and obesity. Clinical studies are needed of promising intervention and prevention strategies. Leveraging existing and future cohort phenotypes, and biological samples is needed for risk factor analysis, biomarker discovery and genome wide association studies.
Authors: Irwin Goldstein; Jay M Young; Jerome Fischer; Keith Bangerter; Thomas Segerson; Terry Taylor Journal: Diabetes Care Date: 2003-03 Impact factor: 19.112
Authors: Katherine Esposito; Francesco Giugliano; Carmen Di Palo; Giovanni Giugliano; Raffaele Marfella; Francesco D'Andrea; Massimo D'Armiento; Dario Giugliano Journal: JAMA Date: 2004-06-23 Impact factor: 56.272
Authors: Fernando S Carneiro; Fernanda R C Giachini; Zidonia N Carneiro; Victor V Lima; Adviye Ergul; R Clinton Webb; Rita C Tostes Journal: J Sex Med Date: 2010-08-30 Impact factor: 3.802
Authors: Irwin Goldstein; LeRoy A Jones; Laurence H Belkoff; Gary S Karlin; Charles H Bowden; Craig A Peterson; Brenda A Trask; Wesley W Day Journal: Mayo Clin Proc Date: 2012-08-01 Impact factor: 7.616
Authors: Yong Sun Choi; Sang Kuon Lee; Woong Jin Bae; Su Jin Kim; Hyuk Jin Cho; Sung-Hoo Hong; Ji Youl Lee; Tae-Kon Hwang; Sae Woong Kim Journal: PLoS One Date: 2014-08-19 Impact factor: 3.240