BACKGROUND: Pyrethroid resistance is now widespread in Anopheles gambiae, the major vector for malaria in sub-Saharan Africa. This resistance may compromise malaria vector control strategies that are currently in use in endemic areas. In this context, a new tool for management of resistant mosquitoes based on the combination of a pyrethroid-treated bed net and carbamate-treated plastic sheeting was developed. METHODS: In the laboratory, the insecticidal activity and wash resistance of four carbamate-treated materials: a cotton/polyester blend, a polyvinyl chloride tarpaulin, a cotton/polyester blend covered on one side with polyurethane, and a mesh of polypropylene fibres was tested. These materials were treated with bendiocarb at 100 mg/m(2) and 200 mg/m(2) with and without a binding resin to find the best combination for field studies. Secondly, experimental hut trials were performed in southern Benin to test the efficacy of the combined use of a pyrethroid-treated bed net and the carbamate-treated material that was the most wash-resistant against wild populations of pyrethroid-resistant An. gambiae and Culex quinquefasciatus. RESULTS: Material made of polypropylene mesh (PPW) provided the best wash resistance (up to 10 washes), regardless of the insecticide dose, the type of washing, or the presence or absence of the binding resin. The experimental hut trial showed that the combination of carbamate-treated PPW and a pyrethroid-treated bed net was extremely effective in terms of mortality and inhibition of blood feeding of pyrethroid-resistant An. gambiae. This efficacy was found to be proportional to the total surface of the walls. This combination showed a moderate effect against wild populations of Cx. quinquefasciatus, which were strongly resistant to pyrethroid. CONCLUSION: These preliminary results should be confirmed, including evaluation of entomological, parasitological, and clinical parameters. Selective pressure on resistance mechanisms within the vector population, effects on other pest insects, and the acceptability of this management strategy in the community also need to be evaluated.
BACKGROUND:Pyrethroid resistance is now widespread in Anopheles gambiae, the major vector for malaria in sub-Saharan Africa. This resistance may compromise malaria vector control strategies that are currently in use in endemic areas. In this context, a new tool for management of resistant mosquitoes based on the combination of a pyrethroid-treated bed net and carbamate-treated plastic sheeting was developed. METHODS: In the laboratory, the insecticidal activity and wash resistance of four carbamate-treated materials: a cotton/polyester blend, a polyvinyl chloride tarpaulin, a cotton/polyester blend covered on one side with polyurethane, and a mesh of polypropylene fibres was tested. These materials were treated with bendiocarb at 100 mg/m(2) and 200 mg/m(2) with and without a binding resin to find the best combination for field studies. Secondly, experimental hut trials were performed in southern Benin to test the efficacy of the combined use of a pyrethroid-treated bed net and the carbamate-treated material that was the most wash-resistant against wild populations of pyrethroid-resistant An. gambiae and Culex quinquefasciatus. RESULTS: Material made of polypropylene mesh (PPW) provided the best wash resistance (up to 10 washes), regardless of the insecticide dose, the type of washing, or the presence or absence of the binding resin. The experimental hut trial showed that the combination of carbamate-treated PPW and a pyrethroid-treated bed net was extremely effective in terms of mortality and inhibition of blood feeding of pyrethroid-resistant An. gambiae. This efficacy was found to be proportional to the total surface of the walls. This combination showed a moderate effect against wild populations of Cx. quinquefasciatus, which were strongly resistant to pyrethroid. CONCLUSION: These preliminary results should be confirmed, including evaluation of entomological, parasitological, and clinical parameters. Selective pressure on resistance mechanisms within the vector population, effects on other pest insects, and the acceptability of this management strategy in the community also need to be evaluated.
Authors: J M Hougard; V Corbel; R N'Guessan; F Darriet; F Chandre; M Akogbéto; T Baldet; P Guillet; P Carnevale; M Traoré-Lamizana Journal: Bull Entomol Res Date: 2003-12 Impact factor: 1.750
Authors: Raphael N'Guessan; Pelagie Boko; Abiba Odjo; Bart Knols; Martin Akogbeto; Mark Rowland Journal: Trop Med Int Health Date: 2009-02-17 Impact factor: 2.622
Authors: Armel Djènontin; Fabrice Chandre; K Roch Dabiré; Joseph Chabi; Raphael N'guessan; Thierry Baldet; Martin Akogbéto; Vincent Corbel Journal: Am J Trop Med Hyg Date: 2010-08 Impact factor: 2.345
Authors: Laura Brosseau; Papa Makhtar Drame; Patrick Besnard; Jean-Claude Toto; Vincent Foumane; Jacques Le Mire; François Mouchet; Franck Remoue; Richard Allan; Filomeno Fortes; Pierre Carnevale; Sylvie Manguin Journal: PLoS One Date: 2012-09-24 Impact factor: 3.240
Authors: Matthew Burns; Mark Rowland; Raphael N'Guessan; Ilona Carneiro; Arlyne Beeche; Stefani Sesler Ruiz; Sarian Kamara; Willem Takken; Pierre Carnevale; Richard Allan Journal: Am J Trop Med Hyg Date: 2012-08 Impact factor: 2.345