Literature DB >> 19841810

Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation.

Keiichi Hattori1, Tomoya Hirohama, Shuhei Imoto, Shuhei Kusano, Fumi Nagatsugi.   

Abstract

Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.

Entities:  

Year:  2009        PMID： 19841810     DOI： 10.1039/b915381k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Sequence-Specific Covalent Capture Coupled with High-Contrast Nanopore Detection of a Disease-Derived Nucleic Acid Sequence.

Authors:  Maryam Imani Nejad; Ruicheng Shi; Xinyue Zhang; Li-Qun Gu; Kent S Gates
Journal:  Chembiochem       Date:  2017-05-26       Impact factor: 3.164

2.  Inducible alkylation of DNA by a quinone methide-peptide nucleic acid conjugate.

Authors:  Yang Liu; Steven E Rokita
Journal:  Biochemistry       Date:  2012-01-24       Impact factor: 3.162

3.  Selective nucleic acid capture with shielded covalent probes.

Authors:  Jeffrey R Vieregg; Hosea M Nelson; Brian M Stoltz; Niles A Pierce
Journal:  J Am Chem Soc       Date:  2013-06-18       Impact factor: 15.419

4.  Selective covalent capture of a DNA sequence corresponding to a cancer-driving C>G mutation in the KRAS gene by a chemically reactive probe: optimizing a cross-linking reaction with non-canonical duplex structures.

Authors:  Xu Guo; Maryam Imani Nejad; Li-Qun Gu; Kent S Gates
Journal:  RSC Adv       Date:  2019-10-15       Impact factor: 4.036

5.  Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine derivatives and structural analysis of the adducts.

Authors:  Shuhei Kusano; Shogo Ishiyama; Sik Lok Lam; Tsukasa Mashima; Masato Katahira; Kengo Miyamoto; Misako Aida; Fumi Nagatsugi
Journal:  Nucleic Acids Res       Date:  2015-08-05       Impact factor: 16.971

6.  4-vinyl-substituted pyrimidine nucleosides exhibit the efficient and selective formation of interstrand cross-links with RNA and duplex DNA.

Authors:  Atsushi Nishimoto; Daichi Jitsuzaki; Kazumitsu Onizuka; Yosuke Taniguchi; Fumi Nagatsugi; Shigeki Sasaki
Journal:  Nucleic Acids Res       Date:  2013-06-18       Impact factor: 16.971
  6 in total

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