Literature DB >> 19841646

Positively selecting peptides: their job does not end in the thymus.

Kai W Wucherpfennig, Etienne Gagnon.   

Abstract

Peptides able to positively select major histocompatibility complex class II-restricted thymocytes have not yet been defined. Two new reports identify and ascribe important extrathymic functions to several positively selecting peptides for CD4+ T cells.

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Year:  2009        PMID： 19841646     DOI： 10.1038/ni1109-1143

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  10 in total

1.  Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity.

Authors:  Michelle Krogsgaard; Qi-Jing Li; Cenk Sumen; Johannes B Huppa; Morgan Huse; Mark M Davis
Journal:  Nature       Date:  2005-02-20       Impact factor: 49.962

2.  Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes.

Authors:  Nathan J Felix; David L Donermeyer; Stephen Horvath; James J Walters; Michael L Gross; Anish Suri; Paul M Allen
Journal:  Nat Immunol       Date:  2007-02-25       Impact factor: 25.606

3.  miR-181a is an intrinsic modulator of T cell sensitivity and selection.

Authors:  Qi-Jing Li; Jacqueline Chau; Peter J R Ebert; Giselle Sylvester; Hyeyoung Min; Gwen Liu; Ravi Braich; Muthiah Manoharan; Juergen Soutschek; Petra Skare; Lawrence O Klein; Mark M Davis; Chang-Zheng Chen
Journal:  Cell       Date:  2007-03-22       Impact factor: 41.582

4.  The repertoire of T cells shaped by a single MHC/peptide ligand.

Authors:  L Ignatowicz; J Kappler; P Marrack
Journal:  Cell       Date:  1996-02-23       Impact factor: 41.582

5.  Specificity and flexibility in thymic selection.

Authors:  S C Jameson; K A Hogquist; M J Bevan
Journal:  Nature       Date:  1994-06-30       Impact factor: 49.962

6.  Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules.

Authors:  J Kirberg; A Berns; H von Boehmer
Journal:  J Exp Med       Date:  1997-10-20       Impact factor: 14.307

7.  An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells.

Authors:  Wan-Lin Lo; Nathan J Felix; James J Walters; Henry Rohrs; Michael L Gross; Paul M Allen
Journal:  Nat Immunol       Date:  2009-10-04       Impact factor: 25.606

8.  An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a.

Authors:  Peter J R Ebert; Shan Jiang; Jianming Xie; Qi-Jing Li; Mark M Davis
Journal:  Nat Immunol       Date:  2009-10-04       Impact factor: 25.606

9.  Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells.

Authors:  G M Davey; S L Schober; B T Endrizzi; A K Dutcher; S C Jameson; K A Hogquist
Journal:  J Exp Med       Date:  1998-11-16       Impact factor: 14.307

10.  Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

Authors:  K A Hogquist; M A Gavin; M J Bevan
Journal:  J Exp Med       Date:  1993-05-01       Impact factor: 14.307
  10 in total
  1 in total

1.  Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicity.

Authors:  Roland S Liblau; Hartmut Wekerle; Roland M Tisch
Journal:  Front Immunol       Date:  2011-10-05       Impact factor: 7.561
  1 in total

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