| Literature DB >> 19841174 |
Rosalie Molenaar1, Mascha Greuter, Arnold P J van der Marel, Ramon Roozendaal, Stefan F Martin, Fanny Edele, Jochen Huehn, Reinhold Förster, Tom O'Toole, Wendy Jansen, Inge L Eestermans, Georg Kraal, Reina E Mebius.
Abstract
T cells are imprinted to express tissue-specific homing receptors upon activation in tissue-draining lymph nodes, resulting in their migration to the site of Ag entry. Expression of gut-homing molecules alpha(4)beta(7) and CCR9 is induced by retinoic acid, a vitamin A metabolite produced by retinal dehydrogenases, which are specifically expressed in dendritic cells as well as stromal cells in mucosa-draining lymph nodes. In this study, we demonstrate that mesenteric lymph node stromal cell-derived retinoic acid can directly induce the expression of gut-homing molecules on proliferating T cells, a process strongly enhanced by bone marrow-derived dendritic cells in vitro. Therefore, cooperation of sessile lymph node stromal cells with mobile dendritic cells warrants the imprinting of tissue specific homing receptors on activated T cells.Entities:
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Year: 2009 PMID： 19841174 DOI： 10.4049/jimmunol.0900311
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422