Literature DB >> 1984007

Effects of topical adenosine analogs and forskolin on rat pial arterioles in vivo.

S Ibayashi1, A C Ngai, J R Meno, H R Winn.   

Abstract

We utilized the closed window technique to study the in vivo responses of rat pial arterioles to superfused adenosine agonists. Adenosine and its analogs dilated pial arterioles and exhibited the following order of potency: 5'N-ethylcarboxamide adenosine (NECA) greater than 2-chloroadenosine (2-CADO) greater than adenosine = R-N6-phenylisopropyladenosine (R-PIA) = S-PIA greater than N6-cyclohexyladenosine (CHA). This potency profile suggests that cerebral vasodilation is mediated through the A2 receptor. Forskolin (10(-9) M) potentiated the vasodilation caused by 10(-6) M NECA, thus implicating adenylate cyclase activation during NECA-induced vasodilation and providing further support for involvement of the A2 receptor.

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Year:  1991        PMID： 1984007     DOI： 10.1038/jcbfm.1991.8

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  6 in total

1.  A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice.

Authors:  J F Chen; Z Huang; J Ma; J Zhu; R Moratalla; D Standaert; M A Moskowitz; J S Fink; M A Schwarzschild
Journal:  J Neurosci       Date:  1999-11-01       Impact factor: 6.167

2.  Multiple effects of adenosine in the arterially perfused mammalian eye. Possible mechanisms for the neuroprotective function of adenosine in the retina.

Authors:  Claudio Macaluso; Laura J Frishman; Beatrice Frueh; Alain Kaelin-Lang; Shoken Onoe; Günter Niemeyer
Journal:  Doc Ophthalmol       Date:  2003-01       Impact factor: 2.379

3.  Adenosine can mediate its actions through generation of reactive oxygen species.

Authors:  Debebe Gebremedhin; Brian Weinberger; David Lourim; David R Harder
Journal:  J Cereb Blood Flow Metab       Date:  2010-06-09       Impact factor: 6.200

4.  Microvascular insulin resistance in skeletal muscle and brain occurs early in the development of juvenile obesity in pigs.

Authors:  T Dylan Olver; Zachary I Grunewald; Thomas J Jurrissen; Rebecca E K MacPherson; Paul J LeBlanc; Teagan R Schnurbusch; Alana M Czajkowski; M Harold Laughlin; R Scott Rector; Shawn B Bender; Eric M Walters; Craig A Emter; Jaume Padilla
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2017-12-04       Impact factor: 3.619

5.  Contribution of adenosine A2A and A2B receptors and heme oxygenase to AMPA-induced dilation of pial arterioles in rats.

Authors:  Hiroto Ohata; Suyi Cao; Raymond C Koehler
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2006-04-06       Impact factor: 3.619

Review 6.  Neurone-to-astrocyte signalling in the brain represents a distinct multifunctional unit.

Authors:  Tommaso Fellin; Giorgio Carmignoto
Journal:  J Physiol       Date:  2004-06-24       Impact factor: 5.182
  6 in total

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