Literature DB >> 19838820

Microarray profile of brain aging-related genes in the frontal cortex of SAMP8.

Shao-Chun Chen1, Gang Lu, Chu-Yan Chan, Yangchao Chen, Hua Wang, David Tai-Wai Yew, Zhong-Tang Feng, Hsiang-Fu Kung.   

Abstract

This study examined the protein expression profile changes in the brain of senescence-accelerated mice/prone 8 (SAMP8) model. Two approaches, namely microarray and RT-PCR, were used in the study. Four genes, which are orthologous to human, were found to differentially express in the aging brain of mice. In this study, we examined the differentially expressed genes in the frontal cortex of the SAMP8 mice of two different ages (4 and 12 month old). Four orthologous genes (i.e., guanine nucleotide binding protein-alpha q polypeptide, kinesin family member 1B, sortilin 1, and somatostatin) showed significant changes in expression with aging. This study may provide important information on the mechanism of aging or aging-related diseases such as Alzheimer's diseases.

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Year:  2009        PMID： 19838820     DOI： 10.1007/s12031-009-9215-6

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  49 in total

1.  Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein.

Authors:  H Fai Poon; Susan A Farr; William A Banks; William M Pierce; Jon B Klein; John E Morley; D Allan Butterfield
Journal:  Brain Res Mol Brain Res       Date:  2005-07-29

2.  Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice.

Authors:  V B Kumar; S A Farr; J F Flood; V Kamlesh; M Franko; W A Banks; J E Morley
Journal:  Peptides       Date:  2000-12       Impact factor: 3.750

3.  Chromosomal localization of three somatostatin genes in zebrafish. Evidence that the [Pro2]-somatostatin-14 isoform and cortistatin are encoded by orthologous genes.

Authors:  Hervé Tostivint; Lucille Joly; Isabelle Lihrmann; Marc Ekker; Hubert Vaudry
Journal:  J Mol Endocrinol       Date:  2004-12       Impact factor: 5.098

4.  Activation and functional characterization of the mosaic receptor SorLA/LR11.

Authors:  L Jacobsen; P Madsen; C Jacobsen; M S Nielsen; J Gliemann; C M Petersen
Journal:  J Biol Chem       Date:  2001-04-09       Impact factor: 5.157

5.  In silico analysis of gene expression profiles in the olfactory mucosae of aging senescence-accelerated mice.

Authors:  Thomas V Getchell; Xuejun Peng; C Paul Green; Arnold J Stromberg; Kuey-Chu Chen; Mark P Mattson; Marilyn L Getchell
Journal:  J Neurosci Res       Date:  2004-08-01       Impact factor: 4.164

6.  Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene.

Authors:  Q Dong; A Shenker; J Way; B R Haddad; K Lin; M R Hughes; O W McBride; A M Spiegel; J Battey
Journal:  Genomics       Date:  1995-12-10       Impact factor: 5.736

7.  Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system.

Authors:  Raya Al-Shawi; Angela Hafner; Jessica Olsen; Jessica Olson; Soyon Chun; Saba Raza; Christopher Thrasivoulou; Simon Lovestone; Richard Killick; Paul Simons; Timothy Cowen
Journal:  Eur J Neurosci       Date:  2008-04       Impact factor: 3.386

8.  The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor.

Authors:  J Mazella; N Zsürger; V Navarro; J Chabry; M Kaghad; D Caput; P Ferrara; N Vita; D Gully; J P Maffrand; J P Vincent
Journal:  J Biol Chem       Date:  1998-10-09       Impact factor: 5.157

9.  Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.

Authors:  Pernille Jansen; Klaus Giehl; Jens R Nyengaard; Kenneth Teng; Oleg Lioubinski; Susanne S Sjoegaard; Tilman Breiderhoff; Michael Gotthardt; Fuyu Lin; Andreas Eilers; Claus M Petersen; Gary R Lewin; Barbara L Hempstead; Thomas E Willnow; Anders Nykjaer
Journal:  Nat Neurosci       Date:  2007-10-14       Impact factor: 24.884

10.  Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice.

Authors:  María I Rodríguez; Germaine Escames; Luis C López; Ana López; José A García; Francisco Ortiz; Darío Acuña-Castroviejo
Journal:  J Pineal Res       Date:  2007-04       Impact factor: 13.007
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  3 in total

1.  The developing, aging neocortex: how genetics and epigenetics influence early developmental patterning and age-related change.

Authors:  Kelly Huffman
Journal:  Front Genet       Date:  2012-10-17       Impact factor: 4.599

2.  Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species.

Authors:  Jason A Bubier; George L Sutphin; Timothy J Reynolds; Ron Korstanje; Axis Fuksman-Kumpa; Erich J Baker; Michael A Langston; Elissa J Chesler
Journal:  PLoS One       Date:  2019-04-12       Impact factor: 3.240

3.  Behavioral and omics analyses study on potential involvement of dipeptide balenine through supplementation in diet of senescence-accelerated mouse prone 8.

Authors:  Nobuhiro Wada; Satoru Yamanaka; Junko Shibato; Randeep Rakwal; Satoshi Hirako; Yuzuru Iizuka; Hyounju Kim; Akiyo Matsumoto; Ai Kimura; Fumiko Takenoya; Genta Yasunaga; Seiji Shioda
Journal:  Genom Data       Date:  2016-09-09
  3 in total

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