Literature DB >> 19838658

[Female patient with type 2 diabetes in coma with metabolic acidosis].

T zur Nieden1, T Conrad.   

Abstract

In case of impaired consciousness, metabolic acidosis with wide anion gap and elevated lactate levels a metformin associated lactic acidosis should be considered in diabetic patients. Taking into account the contraindications to metformin, lactic acidosis is a rare complication, however - if it occurs - fatal in 50-80%. The outcome of the surviving patients is good, once the acute stage is outlived due to immediate hemofiltration.

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Year:  2009        PMID: 19838658     DOI: 10.1007/s00108-009-2375-1

Source DB:  PubMed          Journal:  Internist (Berl)        ISSN: 0020-9554            Impact factor:   0.743


  9 in total

Review 1.  Metformin's contraindications should be contraindicated.

Authors:  James McCormack; Kevin Johns; Hugh Tildesley
Journal:  CMAJ       Date:  2005-08-30       Impact factor: 8.262

Review 2.  Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

Authors:  S Salpeter; E Greyber; G Pasternak; E Salpeter
Journal:  Cochrane Database Syst Rev       Date:  2006-01-25

3.  Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose.

Authors:  M Galea; N Jelacin; K Bramham; I White
Journal:  Br J Anaesth       Date:  2007-02       Impact factor: 9.166

4.  Consequences of metformin intoxication.

Authors:  J D Lalau; C Mourlhon; A Bergeret; C Lacroix
Journal:  Diabetes Care       Date:  1998-11       Impact factor: 19.112

5.  Bicarbonate haemodialysis as a treatment of metformin overdose.

Authors:  D Heaney; A Majid; B Junor
Journal:  Nephrol Dial Transplant       Date:  1997-05       Impact factor: 5.992

6.  Contra-indications to metformin therapy are largely disregarded.

Authors:  A Holstein; D Nahrwold; S Hinze; E H Egberts
Journal:  Diabet Med       Date:  1999-08       Impact factor: 4.359

7.  Incidence of lactic acidosis in metformin users.

Authors:  M Stang; D K Wysowski; D Butler-Jones
Journal:  Diabetes Care       Date:  1999-06       Impact factor: 19.112

8.  Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study.

Authors:  Niklaus Kamber; Wendy A Davis; David G Bruce; Timothy M E Davis
Journal:  Med J Aust       Date:  2008-04-21       Impact factor: 7.738

9.  Lactic acidosis rates in type 2 diabetes.

Authors:  J B Brown; K Pedula; J Barzilay; M K Herson; P Latare
Journal:  Diabetes Care       Date:  1998-10       Impact factor: 19.112

  9 in total
  1 in total

1.  [Rapid blood pH recovery in comatose patients with lactic acidosis is life saving].

Authors:  V Rosival
Journal:  Internist (Berl)       Date:  2010-08       Impact factor: 0.743

  1 in total

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