Literature DB >> 1983853

Human intestine matures as nude mouse xenograft.

H S Winter1, R B Hendren, C H Fox, G J Russell, A Perez-Atayde, A K Bhan, J Folkman.   

Abstract

This report describes a novel system for the study of the development and function of human intestine. Human fetal bowel transplanted into a subcutaneous tunnel on the back of athymic nude (nu/nu) mice develops a new microcirculation within 4 weeks. Tissues undergo morphological development, become similar to adult human bowel tissue, and may survive for 6 months after transplantation. Monoclonal antibody immunoperoxidase staining shows that the epithelial and some endothelial elements are of human phenotype, but the circulating blood cells and migrating mucosal lymphocytes are of mouse origin.

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Year:  1991        PMID： 1983853     DOI： 10.1016/0016-5085(91)90587-b

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  8 in total

Review 1.  Ontogeny, growth and development of the small intestine: Understanding pediatric gastroenterology.

Authors:  Laurie A Drozdowski; Tom Clandinin; Alan B R Thomson
Journal:  World J Gastroenterol       Date:  2010-02-21       Impact factor: 5.742

2.  Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development.

Authors:  Dylan Isaacson; Joel Shen; Mei Cao; Adriane Sinclair; Xuan Yue; Gerald Cunha; Laurence Baskin
Journal:  Differentiation       Date:  2017-09-22       Impact factor: 3.880

3.  Human intestinal epithelial cells produce proinflammatory cytokines in response to infection in a SCID mouse-human intestinal xenograft model of amebiasis.

Authors:  K B Seydel; E Li; P E Swanson; S L Stanley
Journal:  Infect Immun       Date:  1997-05       Impact factor: 3.441

4.  Xenotransplantation of human intestine into mouse abdomen or subcutaneous tissue: Novel platforms for the study of the human enteric nervous system.

Authors:  N Nagy; N Marsiano; R S Bruckner; M Scharl; M J Gutnick; S Yagel; E Arciero; A M Goldstein; N Y Shpigel
Journal:  Neurogastroenterol Motil       Date:  2017-09-08       Impact factor: 3.598

Review 5.  Intestinal mucosal atrophy and adaptation.

Authors:  Darcy Shaw; Kartik Gohil; Marc D Basson
Journal:  World J Gastroenterol       Date:  2012-11-28       Impact factor: 5.742

6.  Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease.

Authors:  James B Canavan; Cristiano Scottà; Anna Vossenkämper; Rimma Goldberg; Matthew J Elder; Irit Shoval; Ellen Marks; Emilie Stolarczyk; Jonathan W Lo; Nick Powell; Henrieta Fazekasova; Peter M Irving; Jeremy D Sanderson; Jane K Howard; Simcha Yagel; Behdad Afzali; Thomas T MacDonald; Maria P Hernandez-Fuentes; Nahum Y Shpigel; Giovanna Lombardi; Graham M Lord
Journal:  Gut       Date:  2015-02-24       Impact factor: 23.059

7.  Fetal endoderm primarily holds the temporal and positional information required for mammalian intestinal development.

Authors:  I Duluc; J N Freund; C Leberquier; M Kedinger
Journal:  J Cell Biol       Date:  1994-07       Impact factor: 10.539

Review 8.  Animal models to study acute and chronic intestinal inflammation in mammals.

Authors:  Janelle A Jiminez; Trina C Uwiera; G Douglas Inglis; Richard R E Uwiera
Journal:  Gut Pathog       Date:  2015-11-10       Impact factor: 4.181
  8 in total

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