Literature DB >> 19838063

PKR is not a universal target of tumor suppressor p53 in response to genotoxic stress.

Mashrur Rahman1, Christopher Lem, Hala Muaddi, Antonis E Koromilas.   

Abstract

It has been recently reported that p53 activation can lead to the induction of PKR-eIF2alpha phosphorylation pathway. However, we demonstrate that PKR and eIF2alpha phosphorylation at serine 51 are not downstream of p53 in response to doxorubicin treatment suggesting that PKR is not a universal target of p53 as proposed.

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Year:  2009        PMID： 19838063     DOI： 10.4161/cc.8.21.9848

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  3 in total

Review 1.  The eIF2α kinases: their structures and functions.

Authors:  Neysan Donnelly; Adrienne M Gorman; Sanjeev Gupta; Afshin Samali
Journal:  Cell Mol Life Sci       Date:  2013-01-26       Impact factor: 9.261

2.  Translation Control by p53.

Authors:  Justina Kasteri; Dibash Das; Xuelin Zhong; Leah Persaud; Ashleigh Francis; Hilal Muharam; Moira Sauane
Journal:  Cancers (Basel)       Date:  2018-05-05       Impact factor: 6.639

3.  Mechanism mediated by a noncoding RNA, nc886, in the cytotoxicity of a DNA-reactive compound.

Authors:  Nawapol Kunkeaw; Yeon-Su Lee; Wonkyun Ronny Im; Jiyoung Joan Jang; Min-Ji Song; Bobae Yang; Jong-Lyul Park; Seon-Young Kim; Yongsuk Ku; Yoosik Kim; Sangmin Kang; Hye-Ram Jo; Jae-Hoon Jeong; Hyun-Sung Lee; Ju-Seog Lee; Hyoung-Pyo Kim; Betty H Johnson; In-Hoo Kim; Yong Sun Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-04       Impact factor: 11.205
  3 in total

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