Literature DB >> 19838055

Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo.

Yunyuan V Wang, Mark Wade, Geoffrey M Wahl.   

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Year:  2009        PMID： 19838055      PMCID： PMC2777705          DOI： 10.4161/cc.8.21.9744

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


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  12 in total

1.  MdmX protects p53 from Mdm2-mediated degradation.

Authors:  M W Jackson; S J Berberich
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

2.  Mutual dependence of MDM2 and MDMX in their functional inactivation of p53.

Authors:  Jijie Gu; Hidehiko Kawai; Linghu Nie; Hiroyuki Kitao; Dmitri Wiederschain; Aart G Jochemsen; John Parant; Guillermina Lozano; Zhi-Min Yuan
Journal:  J Biol Chem       Date:  2002-04-12       Impact factor: 5.157

Review 3.  MDMX: from bench to bedside.

Authors:  Jean-Christophe W Marine; Michael A Dyer; Aart G Jochemsen
Journal:  J Cell Sci       Date:  2007-02-01       Impact factor: 5.285

4.  Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

Authors:  Cynthia LeBron; Lihong Chen; Daniele M Gilkes; Jiandong Chen
Journal:  EMBO J       Date:  2006-03-02       Impact factor: 11.598

Review 5.  Blinded by the Light: The Growing Complexity of p53.

Authors:  Karen H Vousden; Carol Prives
Journal:  Cell       Date:  2009-05-01       Impact factor: 41.582

6.  MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis.

Authors:  Francesca Mancini; Francesca Gentiletti; Marco D'Angelo; Simona Giglio; Simona Nanni; Carmen D'Angelo; Antonella Farsetti; Gennaro Citro; Ada Sacchi; Alfredo Pontecorvi; Fabiola Moretti
Journal:  J Biol Chem       Date:  2003-12-01       Impact factor: 5.157

7.  HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

Authors:  Laëtitia K Linares; Arnd Hengstermann; Aaron Ciechanover; Stefan Müller; Martin Scheffner
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-24       Impact factor: 11.205

8.  Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases.

Authors:  Yunyuan V Wang; Mathias Leblanc; Mark Wade; Aart G Jochemsen; Geoffrey M Wahl
Journal:  Cancer Cell       Date:  2009-07-07       Impact factor: 31.743

9.  In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.

Authors:  Lyubomir T Vassilev; Binh T Vu; Bradford Graves; Daisy Carvajal; Frank Podlaski; Zoran Filipovic; Norman Kong; Ursula Kammlott; Christine Lukacs; Christian Klein; Nader Fotouhi; Emily A Liu
Journal:  Science       Date:  2004-01-02       Impact factor: 47.728

10.  Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation.

Authors:  Yunyuan V Wang; Mark Wade; Eetsin Wong; Yao-Cheng Li; Luo Wei Rodewald; Geoffrey M Wahl
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-17       Impact factor: 11.205
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  6 in total

Review 1.  p53 and Cell Fate: Sensitizing Head and Neck Cancer Stem Cells to Chemotherapy.

Authors:  Christie Rodriguez-Ramirez; Jacques E Nör
Journal:  Crit Rev Oncog       Date:  2018

2.  Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage.

Authors:  Laura A Tollini; Aiwen Jin; Jikyoung Park; Yanping Zhang
Journal:  Cancer Cell       Date:  2014-08-11       Impact factor: 31.743

3.  HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.

Authors:  Anna Phillips; Amina Teunisse; Suzanne Lam; Kirsten Lodder; Matthew Darley; Muhammad Emaduddin; Anja Wolf; Julia Richter; Job de Lange; Matty Verlaan-de Vries; Kristiaan Lenos; Anja Böhnke; Frank Bartel; Jeremy P Blaydes; Aart G Jochemsen
Journal:  J Biol Chem       Date:  2010-07-20       Impact factor: 5.157

4.  p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome.

Authors:  Benjamin T Spike; Geoffrey M Wahl
Journal:  Genes Cancer       Date:  2011-04

Review 5.  Functions of MDMX in the modulation of the p53-response.

Authors:  Kristiaan Lenos; Aart G Jochemsen
Journal:  J Biomed Biotechnol       Date:  2011-03-22

6.  Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade.

Authors:  Alena Mickova; Gvantsa Kharaishvili; Daniela Kurfurstova; Mariam Gachechiladze; Milan Kral; Ondrej Vacek; Barbora Pokryvkova; Martin Mistrik; Karel Soucek; Jan Bouchal
Journal:  Int J Mol Sci       Date:  2021-03-11       Impact factor: 5.923
  6 in total

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