| Literature DB >> 19837998 |
C Hauptmann1, J-C Roulet, J J Niederhauser, W Döll, M E Kirlangic, B Lysyansky, V Krachkovskyi, M A Bhatti, U B Barnikol, L Sasse, C P Bührle, E-J Speckmann, M Götz, V Sturm, H-J Freund, U Schnell, P A Tass.
Abstract
In the past decade deep brain stimulation (DBS)-the application of electrical stimulation to specific target structures via implanted depth electrodes-has become the standard treatment for medically refractory Parkinson's disease and essential tremor. These diseases are characterized by pathological synchronized neuronal activity in particular brain areas. We present an external trial DBS device capable of administering effectively desynchronizing stimulation techniques developed with methods from nonlinear dynamics and statistical physics according to a model-based approach. These techniques exploit either stochastic phase resetting principles or complex delayed-feedback mechanisms. We explain how these methods are implemented into a safe and user-friendly device.Entities:
Mesh：
Year: 2009 PMID： 19837998 DOI： 10.1088/1741-2560/6/6/066003
Source DB: PubMed Journal: J Neural Eng ISSN： 1741-2552 Impact factor: 5.379