Literature DB >> 19837944

Minireview: modulation of hormone receptor signaling by dietary anticancer indoles.

Gary L Firestone1, Shyam N Sundar.   

Abstract

Indole-3-carbinol and its diindole condensation product 3-3'-diindolylmethane are dietary phytochemicals that have striking anticarcinogenic properties in human cancer cells. Molecular, cellular, physiological, and clinical studies have documented that both indole-3-carbinol and 3-3'-diindolylmethane have potent endocrine modulating activities through a myriad of mechanisms. The focus of this review is to discuss the evidence that directly links the anticancer actions of these two indole compounds to the control of steroid receptor and growth factor receptor signaling.

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Year:  2009        PMID： 19837944      PMCID： PMC2796154          DOI： 10.1210/me.2009-0149

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN： 0888-8809


  73 in total

Review 1.  Oestrogen receptors - an overview.

Authors:  E Enmark; J A Gustafsson
Journal:  J Intern Med       Date:  1999-08       Impact factor: 8.989

2.  Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells.

Authors:  Km Wahidur Rahman; Fazlul H Sarkar
Journal:  Cancer Res       Date:  2005-01-01       Impact factor: 12.701

3.  Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.

Authors:  C M Cover; S J Hsieh; E J Cram; C Hong; J E Riby; L F Bjeldanes; G L Firestone
Journal:  Cancer Res       Date:  1999-03-15       Impact factor: 12.701

4.  Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans.

Authors:  J J Michnovicz; H Adlercreutz; H L Bradlow
Journal:  J Natl Cancer Inst       Date:  1997-05-21       Impact factor: 13.506

5.  Inhibition of growth factor-induced Ras signaling in vascular endothelial cells and angiogenesis by 3,3'-diindolylmethane.

Authors:  Xiaofei Chang; Gary L Firestone; Leonard F Bjeldanes
Journal:  Carcinogenesis       Date:  2005-09-30       Impact factor: 4.944

Review 6.  Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators.

Authors:  S Yeh; H C Chang; H Miyamoto; H Takatera; M Rahman; H Y Kang; T H Thin; H K Lin; C Chang
Journal:  Keio J Med       Date:  1999-06

7.  Apoptosis in cervical cancer cells: implications for adjunct anti-estrogen therapy for cervical cancer.

Authors:  Dazhi Chen; Timothy H Carter; Karen J Auborn
Journal:  Anticancer Res       Date:  2004 Sep-Oct       Impact factor: 2.480

8.  Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer.

Authors:  Kathie M Dalessandri; Gary L Firestone; Mark D Fitch; H Leon Bradlow; Leonard F Bjeldanes
Journal:  Nutr Cancer       Date:  2004       Impact factor: 2.900

9.  Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane.

Authors:  I Chen; A McDougal; F Wang; S Safe
Journal:  Carcinogenesis       Date:  1998-09       Impact factor: 4.944

10.  Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells.

Authors:  Urmi Chatterji; Jacques E Riby; Taketoshi Taniguchi; Erik L Bjeldanes; Leonard F Bjeldanes; Gary L Firestone
Journal:  Carcinogenesis       Date:  2004-02-26       Impact factor: 4.944
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  18 in total

1.  DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism.

Authors:  Saijun Fan; Qinghui Meng; Jiaying Xu; Yang Jiao; Lin Zhao; Xiaodong Zhang; Fazlul H Sarkar; Milton L Brown; Anatoly Dritschilo; Eliot M Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-14       Impact factor: 11.205

2.  Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.

Authors:  Jonathan D Lee; Jinfang Zhang; Shu-Yu Lin; Yu-Ru Lee; Ming Chen; Tian-Min Fu; Hao Chen; Tomoki Ishikawa; Shang-Yin Chiang; Jesse Katon; Yang Zhang; Yulia V Shulga; Assaf C Bester; Jacqueline Fung; Emanuele Monteleone; Lixin Wan; Chen Shen; Chih-Hung Hsu; Antonella Papa; John G Clohessy; Julie Teruya-Feldstein; Suresh Jain; Hao Wu; Lydia Matesic; Ruey-Hwa Chen; Wenyi Wei; Pier Paolo Pandolfi
Journal:  Science       Date:  2019-05-17       Impact factor: 47.728

3.  Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin.

Authors:  Mostafa A Elfawal; Melissa J Towler; Nicholas G Reich; Pamela J Weathers; Stephen M Rich
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-05       Impact factor: 11.205

4.  Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.

Authors:  Kevin M Poindexter; Susanne Matthew; Ida Aronchik; Gary L Firestone
Journal:  Cell Biol Toxicol       Date:  2016-04-07       Impact factor: 6.691

5.  Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells.

Authors:  Kris G Hargraves; Lin He; Gary L Firestone
Journal:  Mol Carcinog       Date:  2015-03-19       Impact factor: 4.784

6.  1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.

Authors:  Hanh H Nguyen; Sergey N Lavrenov; Shyam N Sundar; David H H Nguyen; Min Tseng; Crystal N Marconett; Jenny Kung; Richard E Staub; Maria N Preobrazhenskaya; Leonard F Bjeldanes; Gary L Firestone
Journal:  Chem Biol Interact       Date:  2010-06-02       Impact factor: 5.192

Review 7.  Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model.

Authors:  Rosa Divella; Antonella Daniele; Eufemia Savino; Angelo Paradiso
Journal:  Cancer Genomics Proteomics       Date:  2020 Jul-Aug       Impact factor: 4.069

8.  Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.

Authors:  Crystal N Marconett; Shyam N Sundar; Min Tseng; Antony S Tin; Kalvin Q Tran; Kelly M Mahuron; Leonard F Bjeldanes; Gary L Firestone
Journal:  Carcinogenesis       Date:  2011-06-21       Impact factor: 4.944

9.  Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.

Authors:  Crystal N Marconett; Ankur K Singhal; Shyam N Sundar; Gary L Firestone
Journal:  Mol Cell Endocrinol       Date:  2012-07-24       Impact factor: 4.102

10.  The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation.

Authors:  Ida Aronchik; Aishwarya Kundu; Jeanne G Quirit; Gary L Firestone
Journal:  Mol Cancer Res       Date:  2014-07-09       Impact factor: 5.852
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