| Literature DB >> 1983775 |
J G Modell1, J M Mountz, T P Beresford.
Abstract
The authors explore the possible role of basal ganglia/limbic striatal and thalamocortical circuits in craving and loss of control in alcohol abuse and dependence. Alcoholics may suffer from a defect in the neuronal systems within basal ganglia/limbic striatal and thalamocortical neuronal circuits, especially within the striatoaccumbal-ventral pallidal portion of this circuit or its dopaminergic nigrotegmental modulation. Alcoholic craving may result from a neurophysiologically driven obsession resulting from overactivity within the fronto-thalamic neuronal loop, and loss of control of alcohol consumption may be a neurophysiologically driven compulsion resulting from further impairment of the basal ganglia/limbic striatal portion of this circuit caused by the acute dopaminergic effects of intoxication.Entities:
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Year: 1990 PMID： 1983775 DOI： 10.1176/jnp.2.2.123
Source DB: PubMed Journal: J Neuropsychiatry Clin Neurosci ISSN： 0895-0172 Impact factor: 2.198