Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

Literature DB >> 19837589

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

Yan Yin¹, Li Lin, Claudia Ruiz, Michael D Cameron, Jennifer Pocas, Wayne Grant, Thomas Schröter, Weimin Chen, Derek Duckett, Stephan Schürer, Philip Lograsso, Yangbo Feng.

Abstract

A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2009 PMID： 19837589 DOI： 10.1016/j.bmcl.2009.09.115

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

7 in total

1. In silico prediction of ROCK II inhibitors by different classification approaches.

Authors: Chuipu Cai; Qihui Wu; Yunxia Luo; Huili Ma; Jiangang Shen; Yongbin Zhang; Lei Yang; Yunbo Chen; Zehuai Wen; Qi Wang
Journal: Mol Divers Date: 2017-08-02 Impact factor: 2.943

2. Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.

Authors: Yan Yin; Ke Zheng; Nibal Eid; Shannon Howard; Ji-Hak Jeong; Fei Yi; Jia Guo; Chul Min Park; Mathieu Bibian; Weilin Wu; Pamela Hernandez; HaJeung Park; Yuntao Wu; Jun-Li Luo; Philip V LoGrasso; Yangbo Feng
Journal: J Med Chem Date: 2015-02-04 Impact factor: 7.446

3. High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.

Authors: Robert C Reynolds; Subramaniam Ananthan; Ellen Faaleolea; Judith V Hobrath; Cecil D Kwong; Clinton Maddox; Lynn Rasmussen; Melinda I Sosa; Elizabeth Thammasuvimol; E Lucile White; Wei Zhang; John A Secrist
Journal: Tuberculosis (Edinb) Date: 2011-06-25 Impact factor: 3.131

4. Synthesis and evaluation of 6-(¹¹C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET.

Authors: Qingzhen Yu; Katsushi Kumata; Hua Li; Yiding Zhang; Zhen Chen; Xiaofei Zhang; Tuo Shao; Akiko Hatori; Tomoteru Yamasaki; Lin Xie; Kuan Hu; Gangqiang Wang; Lee Josephson; Shaofa Sun; Ming-Rong Zhang; Steven H Liang
Journal: Bioorg Med Chem Lett Date: 2019-12-17 Impact factor: 2.823

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

1. In silico prediction of ROCK II inhibitors by different classification approaches.

2. Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.

3. High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.

4. Synthesis and evaluation of 6-(¹¹C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET.

5. Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).

6. Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents.

Review 7. C-H Carboxylation of Aromatic Compounds through CO₂ Fixation.

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

1. In silico prediction of ROCK II inhibitors by different classification approaches.

2. Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.

3. High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.

4. Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET.

5. Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).

6. Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents.

Review 7. C-H Carboxylation of Aromatic Compounds through CO2 Fixation.

4. Synthesis and evaluation of 6-(¹¹C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET.

Review 7. C-H Carboxylation of Aromatic Compounds through CO₂ Fixation.