Literature DB >> 19837366

Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1.

Peter D Kwong1, John R Mascola, Gary J Nabel.   

Abstract

Monoclonal antibodies that effectively neutralize HIV-1 have been widely sought, yet few have been isolated. Now, technological advances in sera evaluation, B cell stimulation, microneutralization, and antibody cloning have allowed Burton and colleagues to identify two broadly neutralizing monoclonal antibodies, PG9 and PG16, which provide insights for HIV vaccine design.

Entities:  

Mesh:

Substances:

Year:  2009        PMID: 19837366     DOI: 10.1016/j.chom.2009.09.008

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN: 1931-3128            Impact factor:   21.023


  15 in total

Review 1.  Prospects for an HIV vaccine: leading B cells down the right path.

Authors:  Susan Moir; Angela Malaspina; Anthony S Fauci
Journal:  Nat Struct Mol Biol       Date:  2011-12-05       Impact factor: 15.369

2.  A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.

Authors:  Nicole A Doria-Rose; Ivelin Georgiev; Sijy O'Dell; Gwo-Yu Chuang; Ryan P Staupe; Jason S McLellan; Jason Gorman; Marie Pancera; Mattia Bonsignori; Barton F Haynes; Dennis R Burton; Wayne C Koff; Peter D Kwong; John R Mascola
Journal:  J Virol       Date:  2012-05-23       Impact factor: 5.103

Review 3.  Rational antibody-based HIV-1 vaccine design: current approaches and future directions.

Authors:  Laura M Walker; Dennis R Burton
Journal:  Curr Opin Immunol       Date:  2010-03-17       Impact factor: 7.486

4.  Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice.

Authors:  Xilin Wu; Jia Guo; Mengyue Niu; Minghui An; Li Liu; Hui Wang; Xia Jin; Qi Zhang; Ka Shing Lam; Tongjin Wu; Hua Wang; Qian Wang; Yanhua Du; Jingjing Li; Lin Cheng; Hang Ying Tang; Hong Shang; Linqi Zhang; Paul Zhou; Zhiwei Chen
Journal:  J Clin Invest       Date:  2018-04-23       Impact factor: 14.808

5.  Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

Authors:  Jean-Philippe Julien; Jeong Hyun Lee; Albert Cupo; Charles D Murin; Ronald Derking; Simon Hoffenberg; Michael J Caulfield; C Richter King; Andre J Marozsan; Per Johan Klasse; Rogier W Sanders; John P Moore; Ian A Wilson; Andrew B Ward
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-20       Impact factor: 11.205

Review 6.  Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.

Authors:  Jean-Philippe Julien; Peter S Lee; Ian A Wilson
Journal:  Immunol Rev       Date:  2012-11       Impact factor: 12.988

7.  N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function.

Authors:  Marie Pancera; Yongping Yang; Mark K Louder; Jason Gorman; Gabriel Lu; Jason S McLellan; Jonathan Stuckey; Jiang Zhu; Dennis R Burton; Wayne C Koff; John R Mascola; Peter D Kwong
Journal:  PLoS One       Date:  2013-02-19       Impact factor: 3.240

8.  Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.

Authors:  Jean-Philippe Julien; Devin Sok; Reza Khayat; Jeong Hyun Lee; Katie J Doores; Laura M Walker; Alejandra Ramos; Devan C Diwanji; Robert Pejchal; Albert Cupo; Umesh Katpally; Rafael S Depetris; Robyn L Stanfield; Ryan McBride; Andre J Marozsan; James C Paulson; Rogier W Sanders; John P Moore; Dennis R Burton; Pascal Poignard; Andrew B Ward; Ian A Wilson
Journal:  PLoS Pathog       Date:  2013-05-02       Impact factor: 6.823

9.  Isolation of monoclonal antibodies with predetermined conformational epitope specificity.

Authors:  Anton M Sholukh; Muhammad M Mukhtar; Michael Humbert; Sosthène S Essono; Jennifer D Watkins; Hemant K Vyas; Vivekanandan Shanmuganathan; Girish Hemashettar; Maria Kahn; Shiu-Lok Hu; David C Montefiori; Victoria R Polonis; Peter H Schur; Ruth M Ruprecht
Journal:  PLoS One       Date:  2012-06-21       Impact factor: 3.240

10.  HIV-1 superinfection in women broadens and strengthens the neutralizing antibody response.

Authors:  Valerie Cortez; Katherine Odem-Davis; R Scott McClelland; Walter Jaoko; Julie Overbaugh
Journal:  PLoS Pathog       Date:  2012-03-29       Impact factor: 6.823

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.