Literature DB >> 19837049

Synthesis of oligo(ethylene glycol) substituted phosphatidylcholines: secretory PLA2-targeted precursors of NSAID prodrugs.

Renato Rosseto1, Joseph Hajdu.   

Abstract

A series of new phosphatidylcholine analogues with structurally modified sn-2-substituents have been prepared. The synthetic compounds include oligo(ethylene glycol) derivatives with chain-terminal pharmacophores that upon catalytic hydrolysis by phospholipase A(2) yielded a series of oligo(ethylene glycol)-conjugates of the respective drugs. The approach here outlined may open a new way to employ OEG derivatives of phospholipids for therapeutic applications as secretory PLA(2)-targeted precursors of prodrugs.

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Year:  2010        PMID： 19837049      PMCID： PMC2927483          DOI： 10.1016/j.chemphyslip.2009.10.001

Source DB:  PubMed          Journal:  Chem Phys Lipids        ISSN： 0009-3084            Impact factor:   3.329


  46 in total

1.  Design, synthesis, and validation of a branched flexible linker for bioactive peptides.

Authors:  Martina E Bowen; Yasunari Monguchi; Rajesh Sankaranarayanan; Josef Vagner; Lucinda J Begay; Liping Xu; Bhumasamudram Jagadish; Victor J Hruby; Robert J Gillies; Eugene A Mash
Journal:  J Org Chem       Date:  2007-02-06       Impact factor: 4.354

2.  Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice.

Authors:  Meredith A Bostrom; Boris B Boyanovsky; Craig T Jordan; Marilyn P Wadsworth; Douglas J Taatjes; Frederick C de Beer; Nancy R Webb
Journal:  Arterioscler Thromb Vasc Biol       Date:  2007-01-04       Impact factor: 8.311

3.  Differential expression of secretory phospholipases A2 in normal and malignant prostate cell lines: regulation by cytokines, cell signaling pathways, and epigenetic mechanisms.

Authors:  Mario Menschikowski; Albert Hagelgans; Eugene Gussakovsky; Heike Kostka; Elena L Paley; Gabriele Siegert
Journal:  Neoplasia       Date:  2008-03       Impact factor: 5.715

Review 4.  Structural and functional basis of cyclooxygenase inhibition.

Authors:  Anna L Blobaum; Lawrence J Marnett
Journal:  J Med Chem       Date:  2007-03-07       Impact factor: 7.446

Review 5.  Chemical modification of therapeutic drugs or drug vector systems to achieve targeted therapy: looking for the grail.

Authors:  L Juillerat-Jeanneret; F Schmitt
Journal:  Med Res Rev       Date:  2007-07       Impact factor: 12.944

6.  Expression of secretory phospholipase A2s in human atherosclerosis development.

Authors:  Masayo Kimura-Matsumoto; Yukio Ishikawa; Kazuo Komiyama; Tadashi Tsuruta; Makoto Murakami; Seiko Masuda; Yoshikiyo Akasaka; Kinji Ito; Shigeki Ishiguro; Hiroshi Morita; Shinji Sato; Toshiharu Ishii
Journal:  Atherosclerosis       Date:  2007-03-13       Impact factor: 5.162

7.  Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups.

Authors:  Krishnan Malolanarasimhan; Noemi Kedei; Dina M Sigano; James A Kelley; Christopher C Lai; Nancy E Lewin; Robert J Surawski; Vladimir A Pavlyukovets; Susan H Garfield; Stephen Wincovitch; Peter M Blumberg; Victor E Marquez
Journal:  J Med Chem       Date:  2007-02-07       Impact factor: 7.446

Review 8.  Antibacterial actions of secreted phospholipases A2. Review.

Authors:  Timo J Nevalainen; Garry G Graham; Kieran F Scott
Journal:  Biochim Biophys Acta       Date:  2007-12-15

9.  Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology.

Authors:  Andrew S Felts; Chuan Ji; Jennifer B Stafford; Brenda C Crews; Philip J Kingsley; Carol A Rouzer; Mary Kay Washington; Kotha Subbaramaiah; Brianna S Siegel; Shiu M Young; Andrew J Dannenberg; Lawrence J Marnett
Journal:  ACS Chem Biol       Date:  2007-06-29       Impact factor: 5.100

10.  Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate.

Authors:  C M Mounier; D Wendum; E Greenspan; J-F Fléjou; D W Rosenberg; G Lambeau
Journal:  Br J Cancer       Date:  2008-01-22       Impact factor: 7.640
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  1 in total

1.  Peptidophospholipids: synthesis, phospholipase A2 catalyzed hydrolysis, and application to development of phospholipid prodrugs.

Authors:  Renato Rosseto; Joseph Hajdu
Journal:  Chem Phys Lipids       Date:  2014-06-04       Impact factor: 3.329
  1 in total

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