Literature DB >> 19836146

The human superorganism - of microbes and men.

Roy D Sleator.   

Abstract

Albert Einstein once said that "The true value of a human being can be found in the degree to which he has attained liberation from the self". For years our traditional view of 'self' was restricted to our own bodies; composed of eukaryote cells encoded by our genome. However, in the era of omics technologies and systems biology, this view now extends beyond the traditional limitations of our own core being to include our resident microbial communities. These prokaryote cells outnumber our own cells by a factor of ten and contain at least ten times more DNA than our own genome. In exchange for food and shelter, this symbiont provides us, the host, with metabolic functions far beyond the scope of our own physiological capabilities. In this respect the human body can be considered a superorganism; a communal group of human and microbial cells all working for the benefit of the collective - a view which most certainly attains liberation from self.

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Year:  2010        PMID: 19836146     DOI: 10.1016/j.mehy.2009.08.047

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  34 in total

Review 1.  Designer probiotics: Development and applications in gastrointestinal health.

Authors:  Roy D Sleator
Journal:  World J Gastrointest Pathophysiol       Date:  2015-08-15

Review 2.  Under the microscope: From pathogens to probiotics and back.

Authors:  Roy D Sleator
Journal:  Bioengineered       Date:  2015       Impact factor: 3.269

3.  Neonates, antibiotics and the microbiome.

Authors:  Ajitha Thanabalasuriar; Paul Kubes
Journal:  Nat Med       Date:  2014-05       Impact factor: 53.440

4.  Systems biology of eukaryotic superorganisms and the holobiont concept.

Authors:  Ulrich Kutschera
Journal:  Theory Biosci       Date:  2018-06-14       Impact factor: 1.919

5.  The microbiota and microbiome in aging: potential implications in health and age-related diseases.

Authors:  Heidi J Zapata; Vincent J Quagliarello
Journal:  J Am Geriatr Soc       Date:  2015-04-08       Impact factor: 5.562

Review 6.  How poverty affects diet to shape the microbiota and chronic disease.

Authors:  Christy A Harrison; Douglas Taren
Journal:  Nat Rev Immunol       Date:  2017-11-07       Impact factor: 53.106

Review 7.  Pharmacomicrobiomics: the impact of human microbiome variations on systems pharmacology and personalized therapeutics.

Authors:  Marwa ElRakaiby; Bas E Dutilh; Mariam R Rizkallah; Annemarie Boleij; Jason N Cole; Ramy K Aziz
Journal:  OMICS       Date:  2014-05-02

8.  Plant gnotobiology: Epiphytic microbes and sustainable agriculture.

Authors:  Ulrich Kutschera; Rajnish Khanna
Journal:  Plant Signal Behav       Date:  2016-12

9.  Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its future.

Authors:  Stephen Barnes; H Paul Benton; Krista Casazza; Sara J Cooper; Xiangqin Cui; Xiuxia Du; Jeffrey Engler; Janusz H Kabarowski; Shuzhao Li; Wimal Pathmasiri; Jeevan K Prasain; Matthew B Renfrow; Hemant K Tiwari
Journal:  J Mass Spectrom       Date:  2016-08       Impact factor: 1.982

10.  Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells.

Authors:  Valerio Rossini; Katarina Radulovic; Christian U Riedel; Jan Hendrik Niess
Journal:  J Vis Exp       Date:  2016-09-18       Impact factor: 1.355

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