| Literature DB >> 19833514 |
Sonja Nordhoff1, Stephan Bulat, Silvia Cerezo-Gálvez, Oliver Hill, Barbara Hoffmann-Enger, Meritxell López-Canet, Claudia Rosenbaum, Christian Rummey, Meinolf Thiemann, Victor G Matassa, Paul J Edwards, Achim Feurer.
Abstract
For a series of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV ADME properties were improved by the incorporation of amide replacements. These efforts led to a novel series of potent and selective inhibitors of DPP-4 that exhibit an attractive pharmacokinetic profile and show excellent efficacy in an animal model of diabetes.Entities:
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Year: 2009 PMID： 19833514 DOI： 10.1016/j.bmcl.2009.09.078
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823