Literature DB >> 19833513

2'-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743.

Christopher McGuigan1, Marco Derudas, Maurizio Quintiliani, Graciela Andrei, Robert Snoeck, Geoffrey Henson, Jan Balzarini.   

Abstract

We report the preparation of 2'-alpha-F, 2'-beta-F and 2',2'-difluoro analogues of the leading anti-varicella zoster virus (VZV) pentylphenyl BCNA Cf 1743. VZV thymidine kinase showed the highest phosphorylating capacity for the beta-fluoro derivative, that retained equal antiviral potency as the parent compound. In contrast, the alpha-fluoro- and 2',2'-difluoro BCNA derivatives were markedly less (approximately 100-fold) antivirally active.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19833513     DOI： 10.1016/j.bmcl.2009.09.116

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.

Authors:  Maurizio Quintiliani; Leentje Persoons; Nicola Solaroli; Anna Karlsson; Graciela Andrei; Robert Snoeck; Jan Balzarini; Christopher McGuigan
Journal:  Bioorg Med Chem       Date:  2011-05-27       Impact factor: 3.641

2.  Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate.

Authors:  Nadege Hamon; Maurizio Quintiliani; Jan Balzarini; Christopher McGuigan
Journal:  Bioorg Med Chem Lett       Date:  2013-03-14       Impact factor: 2.823

Review 3.  FV-100 for the Treatment of Varicella-Virus (VZV) Infections: Quo Vadis?

Authors:  Erik De Clercq
Journal:  Viruses       Date:  2022-04-07       Impact factor: 5.048
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.