Cairu Li1, Gunnar Engström, Bo Hedblad. 1. Department of Clinical Sciences, Cardiovascular Epidemiology, Lund University, Malmö University Hospital, Malmö, Sweden. cairu.li@med.lu.se
Abstract
OBJECTIVE: Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS: A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascular disease (CVD), were enrolled. Incidence of CE and stroke was studied in relation to leukocyte concentrations over a mean follow-up of 24 years. RESULTS: During the follow-up period, 2600 CE and 1333 stroke events occurred. After risk factor adjustments, leukocyte concentrations in the highest quartile (vs. lowest, >7.0 vs. <4.7 x 10(9)cells/L) were associated with CE in men (HR: 1.31, 95%CI: 1.16-1.48, trend p<0.001), but not significantly in women (HR: 1.46, CI: 0.87-2.46, trend p=0.13). The increased incidence remained significant after adjustments for plasma fibrinogen in a sub-group of 6018 men (HR: 1.31, CI: 1.08-1.60). The association between leukocytes and CE was most pronounced in younger men (aged 27-46) and men without hypertension. In younger men, high leukocytes were associated with early CE (within 10 years of follow-up) and late CE (>10 years of follow-up). In older men (46-61 years), leukocytes were not associated with CE after more than 10 years of follow-up. The leukocyte count was not associated with incidence of stroke. CONCLUSION: Elevated leukocyte count in men is associated with increased incidence of CE, but not with stroke. The increased risk persisted after more than 10 years of follow-up in younger, but not in older men. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
OBJECTIVE: Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS: A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascular disease (CVD), were enrolled. Incidence of CE and stroke was studied in relation to leukocyte concentrations over a mean follow-up of 24 years. RESULTS: During the follow-up period, 2600 CE and 1333 stroke events occurred. After risk factor adjustments, leukocyte concentrations in the highest quartile (vs. lowest, >7.0 vs. <4.7 x 10(9)cells/L) were associated with CE in men (HR: 1.31, 95%CI: 1.16-1.48, trend p<0.001), but not significantly in women (HR: 1.46, CI: 0.87-2.46, trend p=0.13). The increased incidence remained significant after adjustments for plasma fibrinogen in a sub-group of 6018 men (HR: 1.31, CI: 1.08-1.60). The association between leukocytes and CE was most pronounced in younger men (aged 27-46) and men without hypertension. In younger men, high leukocytes were associated with early CE (within 10 years of follow-up) and late CE (>10 years of follow-up). In older men (46-61 years), leukocytes were not associated with CE after more than 10 years of follow-up. The leukocyte count was not associated with incidence of stroke. CONCLUSION: Elevated leukocyte count in men is associated with increased incidence of CE, but not with stroke. The increased risk persisted after more than 10 years of follow-up in younger, but not in older men. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: Ji Young Huh; George Webster Ross; Randi Chen; Robert D Abbott; Christina Bell; Bradley Willcox; Lenore Launer; Helen Petrovitch; Brock Kaya; Kamal Masaki Journal: J Am Geriatr Soc Date: 2015-03-04 Impact factor: 5.562
Authors: Jaana I Halonen; Antonella Zanobetti; David Sparrow; Pantel S Vokonas; Joel Schwartz Journal: Environ Health Date: 2010-07-23 Impact factor: 5.984
Authors: Michael R Elashoff; James A Wingrove; Philip Beineke; Susan E Daniels; Whittemore G Tingley; Steven Rosenberg; Szilard Voros; William E Kraus; Geoffrey S Ginsburg; Robert S Schwartz; Stephen G Ellis; Naheem Tahirkheli; Ron Waksman; John McPherson; Alexandra J Lansky; Eric J Topol Journal: BMC Med Genomics Date: 2011-03-28 Impact factor: 3.063
Authors: Leticia Gomez-Sanchez; Luis García-Ortiz; José I Recio-Rodríguez; Maria C Patino-Alonso; Cristina Agudo-Conde; Fernando Rigo; Rafel Ramos; Ruth Martí; Manuel A Gomez-Marcos Journal: PLoS One Date: 2015-04-17 Impact factor: 3.240
Authors: Nels C Olson; Margaret F Doyle; Nancy Swords Jenny; Sally A Huber; Bruce M Psaty; Richard A Kronmal; Russell P Tracy Journal: PLoS One Date: 2013-08-23 Impact factor: 3.240