Jochen Schmitt1, Thomas Diepgen, Andrea Bauer. 1. Clinic and Policlinic for Dermatology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. jochen.schmitt@uniklinikum-dresden.de
Abstract
BACKGROUND: Although UV exposure is the most important risk factor for cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), a systematic review analyzing the risk of occupational UV exposure is missing. METHODS: Based on a systematic literature search in PubMed (until 05/2009) supplemented by hand search, the association between occupational UV exposure and SCC and BCC was analyzed. Literature search and data abstraction was done independently by 2 reviewers. The association between occupational UV exposure and cancer risk is presented as odds ratios (OR). RESULTS: We identified 25 relevant epidemiologic studies (5 cohort studies, 17 case-control studies, 3 cross-sectional studies). 12 studies described a positive association between occupational UV exposure and risk of SCC with OR > 3 in 6 studies and OR 1.5-2.0 in another 6 studies. 3 studies did not find a relevant association (OR: 1.0-1.4). A significant positive association between occupational UV exposure and BCC was reported in 5 studies; 11 studies did not find a significant association. CONCLUSIONS: The association between occupational UV exposure and SCC is well and consistently documented epidemiologically (approximately 2-fold increased risk), so that the criteria for a new occupational disease are fulfilled. The association with BCC is unclear due to significant methodological limitations in the published studies.
BACKGROUND: Although UV exposure is the most important risk factor for cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), a systematic review analyzing the risk of occupational UV exposure is missing. METHODS: Based on a systematic literature search in PubMed (until 05/2009) supplemented by hand search, the association between occupational UV exposure and SCC and BCC was analyzed. Literature search and data abstraction was done independently by 2 reviewers. The association between occupational UV exposure and cancer risk is presented as odds ratios (OR). RESULTS: We identified 25 relevant epidemiologic studies (5 cohort studies, 17 case-control studies, 3 cross-sectional studies). 12 studies described a positive association between occupational UV exposure and risk of SCC with OR > 3 in 6 studies and OR 1.5-2.0 in another 6 studies. 3 studies did not find a relevant association (OR: 1.0-1.4). A significant positive association between occupational UV exposure and BCC was reported in 5 studies; 11 studies did not find a significant association. CONCLUSIONS: The association between occupational UV exposure and SCC is well and consistently documented epidemiologically (approximately 2-fold increased risk), so that the criteria for a new occupational disease are fulfilled. The association with BCC is unclear due to significant methodological limitations in the published studies.
Authors: Simona Surdu; Edward F Fitzgerald; Michael S Bloom; Francis P Boscoe; David O Carpenter; Richard F Haase; Eugen Gurzau; Peter Rudnai; Kvetoslava Koppova; Joëlle Févotte; Giovanni Leonardi; Marie Vahter; Walter Goessler; Rajiv Kumar; Tony Fletcher Journal: PLoS One Date: 2013-04-24 Impact factor: 3.240
Authors: Luigi Vimercati; Luigi De Maria; Antonio Caputi; Enza Sabrina Silvana Cannone; Francesca Mansi; Domenica Cavone; Paolo Romita; Giuseppe Argenziano; Alessandro Di Stefani; Aurora Parodi; Ketty Peris; Massimiliano Scalvenzi; Giampiero Girolomoni; Caterina Foti Journal: Int J Environ Res Public Health Date: 2020-03-30 Impact factor: 3.390