| Literature DB >> 19832115 |
Misako Yajima1, Ken-Ichi Imadome, Atsuko Nakagawa, Satoru Watanabe, Kazuo Terashima, Hiroyuki Nakamura, Mamoru Ito, Norio Shimizu, Naoki Yamamoto, Shigeyoshi Fujiwara.
Abstract
Humanized NOD/Shi-scid/interleukin-2Rgamma(null) (NOG) mice with full T cell development had significantly longer life span after Epstein-Barr virus (EBV) infection, compared with those with minimal T cell development. Removing CD3(+) or CD8(+) T cells from EBV-infected humanized mice by administration of anti-CD3 or anti-CD8 antibodies reduced their life span. CD8(+) T cells obtained from EBV-infected mice suppressed the outgrowth of autologous B cells isolated from uninfected mice and inoculated with EBV in vitro. These results indicate that humanized NOG mice are capable of T cell-mediated control of EBV infection and imply their usefulness as a tool to evaluate immunotherapeutic and prophylactic strategies for EBV infection.Entities:
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Year: 2009 PMID： 19832115 DOI： 10.1086/644644
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226