Literature DB >> 19832040

Association of polymorphisms in regulatory regions of interleukin-12p40 gene and cytokine serum level with colorectal cancer.

L Miteva1, N Stanilov, T Deliysky, N Mintchev, S Stanilova.   

Abstract

The present study investigates the association between IL12Bpro and +16974A/C in 3' -untranslated region (UTR) polymorphisms of IL12B and IL-12p40 serum level related to development of colorectal cancer (CRC). Our results showed similar distribution of both the investigated polymorphisms among CRC patients and healthy donors, which suggests that these polymorphisms in IL12B were not associated with the development of CRC. However, we found an increased IL-12p40 level in sera from patients compared to healthy donors and the highest level was observed in stage I compared to more advanced stages of CRC. These findings demonstrated that IL-12p40 serum level has an association with the progression of CRC.

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Year:  2009        PMID： 19832040     DOI： 10.3109/07357900902918486

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  12 in total

1.  Monocytes expression of IL-12 related and IL-10 genes in association with development of colorectal cancer.

Authors:  Noyko S Stanilov; Lyuba D Miteva; Zlatka G Dobreva; Jovcho P Jovchev; Geo M Cirovski; Spaska A Stanilova
Journal:  Mol Biol Rep       Date:  2012-10-10       Impact factor: 2.316

2.  Interaction analysis of IL-12A and IL-12B polymorphisms with the risk of colorectal cancer.

Authors:  Ruifen Sun; Fu Jia; Yundan Liang; Lijuan Li; Peng Bai; Fang Yuan; Linbo Gao; Lin Zhang
Journal:  Tumour Biol       Date:  2015-06-24

3.  Functional genetic polymorphisms in interleukin-12B gene in association with systemic lupus erythematosus.

Authors:  Lyuba D Miteva; Irena M Manolova; Mariana G Ivanova; Rasho K Rashkov; Rumen M Stoilov; Maya V Gulubova; Spaska A Stanilova
Journal:  Rheumatol Int       Date:  2010-07-24       Impact factor: 2.631

4.  rs401502 and rs11575934 Polymorphisms of the IL-12 Receptor Beta 1 Gene are Protective Against Colorectal Carcinogenesis.

Authors:  Refka Jelassi; Sabrine Dhouioui; Hamza Ben Salah; Nasreddine Saidi; Nabiha Mzoughi; Radhia Ammi; Aida Bouratbine; Karim Aoun; Ines Zidi; Hanen Chelbi
Journal:  Front Genet       Date:  2022-05-13       Impact factor: 4.772

5.  Interleukin-12B rs3212227 polymorphism and cancer risk: a meta-analysis.

Authors:  Huilong Chen; Sheng Cheng; Jianmiao Wang; Chao Cao; Hansvin Bunjhoo; Weining Xiong; Yongjian Xu
Journal:  Mol Biol Rep       Date:  2012-10-12       Impact factor: 2.316

6.  Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer.

Authors:  Yi-Peng Tao; Wan-Ling Wang; Song-Yue Li; Jian Zhang; Qi-Zhong Shi; Fen Zhao; Bao-Sheng Zhao
Journal:  J Cancer Res Clin Oncol       Date:  2012-06-28       Impact factor: 4.553

7.  Evaluation of the circulating levels of IL-12 and IL-33 in patients with breast cancer: influences of the tumor stages and cytokine gene polymorphisms.

Authors:  Abdollah Jafarzadeh; Kayhan Minaee; Ali-Reza Farsinejad; Maryam Nemati; Arezu Khosravimashizi; Hamid Daneshvar; Mohammad Mehdi Mohammadi; Abdolkarim Sheikhi; Abbas Ghaderi
Journal:  Iran J Basic Med Sci       Date:  2015-12       Impact factor: 2.699

8.  Role of interleukin-12 gene polymorphisms in the onset risk of cancer: a meta-analysis.

Authors:  Yi Zheng; Meng Wang; Tian Tian; Kang Liu; Xinghan Liu; Yajing Zhai; Shuai Lin; Pengtao Yang; Shanli Li; Zhijun Dai; Jun Lu
Journal:  Oncotarget       Date:  2017-05-02

9.  Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan.

Authors:  Te-Chun Shen; Chia-Wen Tsai; Wen-Shin Chang; Shengyu Wang; Che-Yi Chao; Chieh-Lun Hsiao; Wei-Chun Chen; Te-Chun Hsia; Da-Tian Bau
Journal:  Sci Rep       Date:  2017-06-09       Impact factor: 4.379

10.  No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis.

Authors:  Christiane S Eberhardt; Johannes-Peter Haas; Hermann Girschick; Tobias Schwarz; Henner Morbach; Angela Rösen-Wolff; Dirk Foell; Guenther Dannecker; Carsten Schepp; Gerd Ganser; Nora Honke; Thomas Eggermann; Jan Müller-Berghaus; Norbert Wagner; Kim Ohl; Klaus Tenbrock
Journal:  Pediatr Rheumatol Online J       Date:  2015-12-15       Impact factor: 3.054
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