| Literature DB >> 19832036 |
Weiguo Zhang1, Qiang Tong, Qingming Wu, Shengbao Li, Xiaohu Wang, Qiang Wang.
Abstract
Previous study indicated that p27kip1 gene transfer can obviously inhibit the growth of some carcinoma cells. The purpose of this study was to investigate anticarcinoma mechanism of p27kip1. Gastric carcinoma cell strain SGC-7901 was transfected with recombinant adenovirus vector carrying human p27kip1 gene (Ad-p27kip1). Expression of survivin was detected using the western blot method and activity of telomerase was examined by telomeric repeat amplification protocol (TRAP) PCR-ELISA in gastric carcinoma cells. Our results suggest that upregulated p27kip1 can downregulate survivin expression and inhibit telomerase activity in gastric carcinoma cells.Entities:
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Year: 2009 PMID： 19832036 DOI： 10.3109/07357900902918478
Source DB: PubMed Journal: Cancer Invest ISSN： 0735-7907 Impact factor: 2.176