BACKGROUND: Cross-sectional research has demonstrated poorer function and health-related quality of life (HRQOL) in those with multiple sclerosis (MS) but less is known about change over time. The goals of this study were to measure change in HRQOL and identify factors associated with change. METHODS: HRQOL was assessed at baseline and annually over two subsequent years using the Multiple Sclerosis Quality of Life Inventory. Function was assessed using the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite. Annualized rate of change was calculated for all twenty outcomes. Mixed effects modeling (univariate followed by multivariate) was used to examine the associations among patient characteristics and the age- and sex-adjusted Physical Component Summary (PCS) and Mental Component Summary (MCS) at study initiation and over the two years of follow-up. RESULTS: Of 300 participants, 288 (96%) provided at least one assessment and are included in this analysis. Although 14 of the 20 outcomes showed a mean decline, only two (SF-36 physical function, p=0.018 and the EDSS, p<0.001) were statistically significant. The SF-36 social function showed a significant improvement (p=0.031). Only two variables were significantly associated with a decreased rate of decline or improvement over two years, including being female (PCS, p=0.001) and use of visiting nurse services (MCS, p<0.001). CONCLUSIONS: HRQOL is relatively stable over two years of follow-up, particularly for mentally-oriented outcomes. Further research with a longer period of follow-up is needed to provide additional insight into factors associated with change in HRQOL in patients with MS.
BACKGROUND: Cross-sectional research has demonstrated poorer function and health-related quality of life (HRQOL) in those with multiple sclerosis (MS) but less is known about change over time. The goals of this study were to measure change in HRQOL and identify factors associated with change. METHODS: HRQOL was assessed at baseline and annually over two subsequent years using the Multiple Sclerosis Quality of Life Inventory. Function was assessed using the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite. Annualized rate of change was calculated for all twenty outcomes. Mixed effects modeling (univariate followed by multivariate) was used to examine the associations among patient characteristics and the age- and sex-adjusted Physical Component Summary (PCS) and Mental Component Summary (MCS) at study initiation and over the two years of follow-up. RESULTS: Of 300 participants, 288 (96%) provided at least one assessment and are included in this analysis. Although 14 of the 20 outcomes showed a mean decline, only two (SF-36 physical function, p=0.018 and the EDSS, p<0.001) were statistically significant. The SF-36 social function showed a significant improvement (p=0.031). Only two variables were significantly associated with a decreased rate of decline or improvement over two years, including being female (PCS, p=0.001) and use of visiting nurse services (MCS, p<0.001). CONCLUSIONS: HRQOL is relatively stable over two years of follow-up, particularly for mentally-oriented outcomes. Further research with a longer period of follow-up is needed to provide additional insight into factors associated with change in HRQOL in patients with MS.
Authors: Julia O'Mahony; Amber Salter; Beyza Ciftci; Robert J Fox; Gary R Cutter; Ruth Ann Marrie Journal: Neurology Date: 2022-08-10 Impact factor: 11.800
Authors: Darija Kisic Tepavcevic; Tatjana Pekmezovic; Nebojsa Stojsavljevic; Jelena Kostic; Irena Dujmovic Basuroski; Sarlota Mesaros; Jelena Drulovic Journal: Qual Life Res Date: 2013-10-01 Impact factor: 4.147
Authors: Laura Rosa; Maria Petracca; Antonio Carotenuto; Pasquale Dolce; Kyrie Piscopo; Francesca Dicé; Francesca Lauro; Antonio Luca Spiezia; Marcello Moccia; Luigi Lavorgna; Carmine Iacovazzo; Giuseppe Servillo; Nelson Mauro Maldonato; Alessandro Chiodi; Vincenzo Brescia Morra; Roberta Lanzillo Journal: J Clin Med Date: 2022-09-04 Impact factor: 4.964
Authors: Una Nedeljkovic; Jelena Dackovic; Darija Kisic Tepavcevic; Irena Dujmovic Basuroski; Sarlota Mesaros; Tatjana Pekmezovic; Jelena Drulovic Journal: Arch Med Sci Date: 2015-03-18 Impact factor: 3.318