Literature DB >> 19830284

Hydrolytic activity of histidine-containing octapeptides in water identified by quantitative screening of a combinatorial library.

Carsten Schmuck1, Ute Michels, Jürgen Dudaczek.   

Abstract

A quantitative on-bead screening of a combinatorial octapeptide library revealed catalysts with hydrolytic activity in water. Histidine is an essential amino acid but the catalytic activity as well as the substrate binding affinity is also dependent on the sequence of the octapeptide.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19830284     DOI： 10.1039/b904415a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  2 in total

1.  The role of β-hairpin conformation in ester hydrolysis peptide catalysts based on a TrpZip scaffold.

Authors:  Xinyu Liu; Riley Waters; Hannah E Gilbert; Gage T Barroso; Kelsey M Boyle; Leah S Witus
Journal:  RSC Adv       Date:  2021-07-06       Impact factor: 4.036

2.  Alternative application of an affinity purification tag: hexahistidines in ester hydrolysis.

Authors:  Lise Schoonen; Kayleigh S van Esterik; Chunqiu Zhang; Rein V Ulijn; Roeland J M Nolte; Jan C M van Hest
Journal:  Sci Rep       Date:  2017-11-07       Impact factor: 4.379
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.