INTRODUCTION: We report a case of sero-negative celiac disease in Pakistan. CASE PRESENTATION: A 20-year-old female presented with papulovesicular rash for 15 years, diarrhea for 8 years, spasms of hands and twitching of face for 4-5 months. She had mild anemia, low vitamin-D3 and serum calcium. On exclusion of other causes of malabsorption, anti-tissue transglutaminase antibodies (immunoglobulin-A & immunoglobulin-G), anti-endomysial antibodies, total immunoglobulin-A levels and skin biopsy were performed, which were normal. Intestinal biopsy revealed subtotal villous atrophy. Patient was prescribed gluten-free diet, to which she responded with alleviation of symptoms. CONCLUSION: Negative serology should not rule out celiac disease; intestinal biopsy should be performed if there is strong clinical suspicion.
INTRODUCTION: We report a case of sero-negative celiac disease in Pakistan. CASE PRESENTATION: A 20-year-old female presented with papulovesicular rash for 15 years, diarrhea for 8 years, spasms of hands and twitching of face for 4-5 months. She had mild anemia, low vitamin-D3 and serum calcium. On exclusion of other causes of malabsorption, anti-tissue transglutaminase antibodies (immunoglobulin-A & immunoglobulin-G), anti-endomysial antibodies, total immunoglobulin-A levels and skin biopsy were performed, which were normal. Intestinal biopsy revealed subtotal villous atrophy. Patient was prescribed gluten-free diet, to which she responded with alleviation of symptoms. CONCLUSION: Negative serology should not rule out celiac disease; intestinal biopsy should be performed if there is strong clinical suspicion.
Authors: A Carroccio; G Iacono; D D'Amico; F Cavataio; S Teresi; C Caruso; Prima L Di; A Colombo; F D'Arpa; A Florena; A Notarbartolo; G Montalto Journal: Scand J Gastroenterol Date: 2002-01 Impact factor: 2.423
Authors: Pekka Collin; Katri Kaukinen; Harald Vogelsang; Ilma Korponay-Szabó; Rudolf Sommer; Elisabeth Schreier; Umberto Volta; Alessandro Granito; Lorenza Veronesi; Françoise Mascart; Annick Ocmant; Anneli Ivarsson; Carina Lagerqvist; Annemarie Bürgin-Wolff; Faruk Hadziselimovic; Raoul I Furlano; Marc A Sidler; Chris J J Mulder; Marije S Goerres; M Luisa Mearin; Maarten K Ninaber; Eivind Gudmand-Høyer; Elisabetta Fabiani; Carlo Catassi; Helena Tidlund; Lisbeth Alainentalo; Markku Mäki Journal: Eur J Gastroenterol Hepatol Date: 2005-01 Impact factor: 2.566