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Literature DB >> 19829160

Age-related changes in serum and brain levels of androgens in male Brown Norway rats.

Emily R Rosario¹, Lilly Chang, Tina L Beckett, Jenna C Carroll, M Paul Murphy, Frank Z Stanczyk, Christian J Pike.

Abstract

Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble beta-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with beta-amyloid levels that may be relevant to Alzheimer's disease risk.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2009 PMID： 19829160 PMCID： PMC6042843 DOI： 10.1097/WNR.0b013e328331f968

Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837

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Review 6. Male reproductive ageing: using the brown Norway rat as a model for man.

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7. 3alpha-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats.

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