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Literature DB >> 19828347

Genetic variability of innate immunity impacts human susceptibility to fungal diseases.

Agostinho Carvalho¹, Cristina Cunha, Alessandro C Pasqualotto, Lucia Pitzurra, David W Denning, Luigina Romani.

Abstract

Fungi are a major threat in immunocompromised patients. Despite presenting similar degrees of immunosuppression, not all individuals at-risk ultimately develop fungal diseases. The traditional view of immune suppression as a key risk factor for susceptibility to fungal infections needs to be accommodated within new conceptual advances on host immunity and its relationship to fungal disease. The critical role of the immune system emphasizes the contribution of host genetic polymorphisms to fungal disease susceptibility. This review highlights the present knowledge on innate immunity genetics that associates with susceptibility to fungal diseases. Copyright 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Entities: Disease Species

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Year: 2009 PMID： 19828347 DOI： 10.1016/j.ijid.2009.06.028

Source DB: PubMed Journal: Int J Infect Dis ISSN： 1201-9712 Impact factor: 3.623

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Cited

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