Innate immunity and allergy in the skin.

The skin as an organ has many functions of which the protection against environmental threats may be the most important. Recent investigations have broadened our understanding of the cellular mechanisms of host defense responses of the skin. Interestingly, the three key effector cells of cutaneous innate immunity, that is keratinocytes, dendritic cells, and mast cells, are also critically involved in the elicitation of allergic reactions. Keratinocytes keep bacteria and other pathogens from invading the host, but they can also promote the development of allergic asthma by releasing thymic stromal lymphopoietin. Dendritic cells in the skin are crucial for the detection and processing of allergens and thus for the development of allergies, but they are also essential in host defense against bacteria, for example by releasing cytokines such as TNF and IL-17. Mast cells, the most important effector cells in immediate hypersensitivity type allergic reactions, effectively combat bacterial infections, for example by releasing antimicrobial peptides.