| Literature DB >> 19828154 |
Franziska Di Pauli1, Viktoria Gredler, Bettina Kuenz, Andreas Lutterotti, Rainer Ehling, Claudia Gneiss, Michael Schocke, Florian Deisenhammer, Markus Reindl, Thomas Berger.
Abstract
We have analyzed immunoglobulin (Ig) isotypes and IgG subclasses in cerebrospinal fluid (CSF) and serum of patients with multiple sclerosis (MS) and other neurological diseases to determine whether different Ig isotype patterns correlate with clinical or paraclinical findings and CSF B cell populations. Intrathecal IgG1 synthesis was elevated in MS patients. An increased intrathecal IgM production was found in patients with a higher cerebral MRI lesion burden, whereas other clinical and paraclinical parameters were not associated with a specific Ig isotype or subclass profile. Finally, intrathecal IgG production (IgG1 and IgG3) correlated with the presence of mature B cells and plasma blasts.Entities:
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Year: 2009 PMID： 19828154 DOI： 10.1016/j.jns.2009.09.016
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181