Neuroimmune biology of physical exercise.

Physical inactivity plays a negative role in several aspects of health status. A sedentary lifestyle represents a predisposing base for the development of obesity, type 2 diabetes, cardiovascular disease, osteoporosis, depression and cancer. On the other hand, an active life is distinguished by physical exercise and the beneficial effects it brings to health, reducing the risk of contracting these diseases. The general state of exercise-related psycho-physical health is regulated by a variety of mechanisms that affect the highly integrated and synergistic responses of the central nervous system and efficiency of the overall immune system. There is positive evidence concerning the influence of neuro-immune systems on the status of health, during moderate and regular physical exercise.