Literature DB >> 19827766

Novel cyclic hexapeptides from marine-derived fungus, Aspergillus sclerotiorum PT06-1.

Jinkai Zheng1, Huajie Zhu, Kui Hong, Yi Wang, Peipei Liu, Xin Wang, Xiaoping Peng, Weiming Zhu.   

Abstract

Two novel cyclic hexapeptides containing both anthranilic acid and dehydroamino acid units, sclerotides A (1) and B (2), were isolated from the marine-derived halotolerant Aspergillus sclerotiorum PT06-1 in a nutrient-limited hypersaline medium. Both 1 and 2 are photointerconvertible and could be interconverted via a radical reaction initiated by direct photoisomerization. Both compounds showed moderate antifungal activity. Compound 2 also showed weak cytotoxicity and antibacterial activity.

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Year:  2009        PMID: 19827766     DOI: 10.1021/ol902197z

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  23 in total

Review 1.  Marine-derived Aspergillus species as a source of bioactive secondary metabolites.

Authors:  Yoon Mi Lee; Min Jeong Kim; Huayue Li; Ping Zhang; Baoquan Bao; Ka Jeong Lee; Jee H Jung
Journal:  Mar Biotechnol (NY)       Date:  2013-05-25       Impact factor: 3.619

Review 2.  Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology.

Authors:  Vedanjali Gogineni; Mark T Hamann
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-08-24       Impact factor: 3.770

3.  Anthranilic acid-containing cyclic tetrapeptides: at the crossroads of conformational rigidity and synthetic accessibility.

Authors:  Dongyue Xin; Kevin Burgess
Journal:  Org Biomol Chem       Date:  2016-05-13       Impact factor: 3.876

4.  Multilocus Phylogeny and Antifungal Susceptibility of Aspergillus Section Circumdati from Clinical Samples and Description of A. pseudosclerotiorum sp. nov.

Authors:  J P Z Siqueira; D A Sutton; J Gené; D García; N Wiederhold; S W Peterson; J Guarro
Journal:  J Clin Microbiol       Date:  2017-01-04       Impact factor: 5.948

Review 5.  Marine Cyclic Peptides: Antimicrobial Activity and Synthetic Strategies.

Authors:  Ricardo Ribeiro; Eugénia Pinto; Carla Fernandes; Emília Sousa
Journal:  Mar Drugs       Date:  2022-06-15       Impact factor: 6.085

6.  Antimicrobial ergosteroids and pyrrole derivatives from halotolerant Aspergillus flocculosus PT05-1 cultured in a hypersaline medium.

Authors:  Jinkai Zheng; Yi Wang; Junfeng Wang; Peipei Liu; Jing Li; Weiming Zhu
Journal:  Extremophiles       Date:  2013-09-13       Impact factor: 2.395

7.  Three new compounds from Aspergillus terreus PT06-2 grown in a high salt medium.

Authors:  Yi Wang; Jinkai Zheng; Peipei Liu; Wei Wang; Weiming Zhu
Journal:  Mar Drugs       Date:  2011-08-12       Impact factor: 6.085

8.  Effects of high salt stress on secondary metabolite production in the marine-derived fungus Spicaria elegans.

Authors:  Yi Wang; Zhenyu Lu; Kunlai Sun; Weiming Zhu
Journal:  Mar Drugs       Date:  2011-03-31       Impact factor: 6.085

9.  Two novel hepatocellular carcinoma cycle inhibitory cyclodepsipeptides from a hydrothermal vent crab-associated fungus Aspergillus clavatus C2WU.

Authors:  Wei Jiang; Panpan Ye; Chen-Tung Arthur Chen; Kuiwu Wang; Pengyuan Liu; Shan He; Xiaodan Wu; Lishe Gan; Ying Ye; Bin Wu
Journal:  Mar Drugs       Date:  2013-12-02       Impact factor: 5.118

Review 10.  α,β-Dehydroamino acids in naturally occurring peptides.

Authors:  Dawid Siodłak
Journal:  Amino Acids       Date:  2014-10-17       Impact factor: 3.520

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