Literature DB >> 1982768

Tubulosine: an antitumor constituent of Pogonopus speciosus.

W W Ma1, J E Anderson, A T McKenzie, S R Byrn, J L McLaughlin, M S Hudson.   

Abstract

From the antitumor-bioactive sap of Pogonopus speciosus, tubulosine [1] was isolated, by activity-directed fractionation using the brine shrimp lethality test, as the major antitumor constituent. 1H-nmr assignments, obtained from HETCOR and COSY, and X-ray crystallographic results are reported for the first time. Psychotrine [2] was also isolated, and its spectral data are also reported.

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Year:  1990        PMID: 1982768     DOI: 10.1021/np50070a041

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  7 in total

1.  Molecular modeling study of tubulosine and other related ipecac alkaloids.

Authors:  M Troconis; W Ma; D E Nichols; J McLaughlin
Journal:  J Comput Aided Mol Des       Date:  1998-09       Impact factor: 3.686

2.  A divergent strategy for the synthesis of secologanin derived natural products.

Authors:  Brandon J English; Robert M Williams
Journal:  J Org Chem       Date:  2010-10-22       Impact factor: 4.354

3.  Tubulosine selectively inhibits JAK3 signalling by binding to the ATP-binding site of the kinase of JAK3.

Authors:  Byung-Hak Kim; Eun Hee Yi; Jun-Goo Jee; Ae Jin Jeong; Claudio Sandoval; In-Chul Park; Gyeong Hun Baeg; Sang-Kyu Ye
Journal:  J Cell Mol Med       Date:  2020-06-17       Impact factor: 5.310

4.  Bifunctional catalysis: direct reductive amination of aliphatic ketones with an iridium-phosphate catalyst.

Authors:  Barbara Villa-Marcos; Chaoqun Li; Keith R Mulholland; Philip J Hogan; Jianliang Xiao
Journal:  Molecules       Date:  2010-04-08       Impact factor: 4.411

5.  Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling.

Authors:  Byung-Hak Kim; Eun Hee Yi; Yu-Chen Li; In-Chul Park; Jung Youl Park; Sang-Kyu Ye
Journal:  J Breast Cancer       Date:  2019-08-02       Impact factor: 3.588

6.  The Wide Potential Trophic Niche of the Asiatic Fruit Fly Drosophila suzukii: The Key of Its Invasion Success in Temperate Europe?

Authors:  Mathilde Poyet; Vincent Le Roux; Patricia Gibert; Antoine Meirland; Geneviève Prévost; Patrice Eslin; Olivier Chabrerie
Journal:  PLoS One       Date:  2015-11-18       Impact factor: 3.240

7.  Establishing the concept of aza-[3 + 3] annulations using enones as a key expansion of this unified strategy in alkaloid synthesis.

Authors:  Aleksey I Gerasyuto; Zhi-Xiong Ma; Grant S Buchanan; Richard P Hsung
Journal:  Beilstein J Org Chem       Date:  2013-06-18       Impact factor: 2.883

  7 in total

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