| Literature DB >> 19825955 |
Heather L McArthur1, Clifford A Hudis.
Abstract
Preclinical and clinical models of HER2-positive breast cancer show that human epidermal growth factor receptor 2 (HER2)-targeted therapy with trastuzumab adds significant benefits and modest risks to conventional cytotoxic therapies. Building on this advance will likely depend on elucidation of relevant signaling pathways and mechanisms of action for effective HER2-targeted therapies.Entities:
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Year: 2009 PMID： 19825955 DOI： 10.1158/1078-0432.CCR-09-1917
Source DB: PubMed Journal: Clin Cancer Res ISSN： 1078-0432 Impact factor: 12.531