Aortic valve stenosis.

Calcific aortic stenosis (AS) is primarily a disease of the elderly, possessing features that are biomechanical as well as systemic and inflammatory in nature, with risk factors and histopathology similar to atherosclerosis. To date no medical therapy has been shown to conclusively alter the progression of the disease, and for those with symptomatic AS, aortic valve replacement (AVR) is advocated. Factors that may alert the physician to an accelerated progression of calcific aortic valvular disease toward severe symptomatic AS include moderate aortic valve calcification, chronically dialyzed patients, and patients 80 years and older. There remains significant morbidity and mortality associated with AVR, and new techniques and technologies for AVR are being developed. For those who undergo successful AVR the long-term prognosis is good. A substantial number of patients with symptomatic AS present for anesthesia care for a variety of procedures. A thorough, modern understanding of AS and its course are necessary for the anesthesiologist to guide the patient through the perioperative period.