| Literature DB >> 19825384 |
Antony Gomes1, Sourav Bhattacharya, Mousumi Chakraborty, Pushpak Bhattacharjee, Roshnara Mishra, Aparna Gomes.
Abstract
The Indian Monocellate Cobra venom (NKV) showed anti-arthritic activity over FCA induced arthritis in male albino rats. NKV treatment (1/20th & 1/10th MLD doses x 13 days, i.p.) showed significant restoration in paw & ankle volume, paw weight. Urinary hydroxyproline, glucosamine, serum ACP, ALP and IL-10 level were restored significantly, due to NKV treatment, as compared with arthritic rats. NKV also showed significant protection against arthritis induced oxidative damages. Thus this study confirmed the scientific validation behind ancient belief and use of snake venom in arthritis as mentioned in Ayurveda. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19825384 DOI： 10.1016/j.toxicon.2009.10.007
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033