OBJECTIVE: To determine if substance use (particularly cannabis) is more frequent among first episode psychosis patients and associated with a more problematic clinical presentation. METHOD: All first episode psychosis (FEP) patients presenting to secondary services were recruited from London and Nottingham, over 2 years, in the Aetiology and Ethnicity of Schizophrenia and Other Psychoses study broad framework. Clinical and sociodemographic variables were assessed using a set of standardized instruments. A schedule was created to retrospectively collate substance use data from patients, relatives and clinicians. RESULTS: Five hundred and eleven FEP were identified. They used three to five times more substances than general population. Substance use was associated with poorer social adjustment and a more acute mode of onset. Cannabis use did not affect social adjustment, but was associated with a more acute mode of onset. CONCLUSION: Cannabis has a different impact on FEP than other substances. Large epidemiological studies are needed to disentangle cannabis effect.
OBJECTIVE: To determine if substance use (particularly cannabis) is more frequent among first episode psychosispatients and associated with a more problematic clinical presentation. METHOD: All first episode psychosis (FEP) patients presenting to secondary services were recruited from London and Nottingham, over 2 years, in the Aetiology and Ethnicity of Schizophrenia and Other Psychoses study broad framework. Clinical and sociodemographic variables were assessed using a set of standardized instruments. A schedule was created to retrospectively collate substance use data from patients, relatives and clinicians. RESULTS: Five hundred and eleven FEP were identified. They used three to five times more substances than general population. Substance use was associated with poorer social adjustment and a more acute mode of onset. Cannabis use did not affect social adjustment, but was associated with a more acute mode of onset. CONCLUSION: Cannabis has a different impact on FEP than other substances. Large epidemiological studies are needed to disentangle cannabis effect.
Authors: Ruth Salo; Catherine Fassbender; Ana-Maria Iosif; Stefan Ursu; Martin H Leamon; Cameron Carter Journal: Psychiatry Res Date: 2013-07-26 Impact factor: 3.222
Authors: Jean Addington; Nevicia Case; Majid M Saleem; Andrea M Auther; Barbara A Cornblatt; Kristin S Cadenhead Journal: Early Interv Psychiatry Date: 2013-11-14 Impact factor: 2.732
Authors: Leslie Marino; Samantha E Jankowski; Rick Kent; Michael L Birnbaum; Ilana Nossel; Jean-Marie Alves-Bradford; Lisa Dixon Journal: Early Interv Psychiatry Date: 2021-05-16 Impact factor: 2.732
Authors: James B Kirkbride; Antonia Errazuriz; Tim J Croudace; Craig Morgan; Daniel Jackson; Jane Boydell; Robin M Murray; Peter B Jones Journal: PLoS One Date: 2012-03-22 Impact factor: 3.240