Literature DB >> 1982242

Amyloid beta/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia.

H Yamaguchi1, K Ishiguro, M Shoji, T Yamazaki, Y Nakazato, Y Ihara, S Hirai.   

Abstract

Localization of amyloid beta/A4 protein precursor (APP) in Alzheimer's neurofibrillary tangles (NFT) was examined immunohistochemically. Antiserum directed to N-terminal of APP intensely labeled intracellular NFT and some neuropil threads. The NFT, extracted from Alzheimer brains by detergent treatments, were also immunoreactive with this antiserum. Antisera to other parts of APP labeled NFT after the formic acid pretreatment. However, Western blot analysis of NFT demonstrated no immunoreactive bands with APP antiserum. These findings suggest that APP is a minor component of the NFT.

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Year:  1990        PMID： 1982242     DOI： 10.1016/0006-8993(90)90377-n

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  19 in total

1.  Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease.

Authors:  G Perry; P Cras; S L Siedlak; M Tabaton; M Kawai
Journal:  Am J Pathol       Date:  1992-02       Impact factor: 4.307

2.  Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia.

Authors:  H Yamaguchi; Y Nakazato; T Kawarabayashi; K Ishiguro; Y Ihara; M Morimatsu; S Hirai
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

3.  Tangle-associated neuritic clusters. A new lesion in Alzheimer's disease and aging suggests that aggregates of dystrophic neurites are not necessarily associated with beta/A4.

Authors:  D G Munoz; D Wang
Journal:  Am J Pathol       Date:  1992-05       Impact factor: 4.307

4.  Carboxyl-terminal fragments of beta-amyloid precursor protein bind to microtubules and the associated protein tau.

Authors:  K Islam; E Levy
Journal:  Am J Pathol       Date:  1997-07       Impact factor: 4.307

Review 5.  The role of beta-amyloid in the development of Alzheimer's disease.

Authors:  K Ii
Journal:  Drugs Aging       Date:  1995-08       Impact factor: 3.923

Review 6.  Probing modifications of the neuronal cytoskeleton.

Authors:  L C Doering
Journal:  Mol Neurobiol       Date:  1993 Fall-Winter       Impact factor: 5.590

7.  Immunocytochemical evidence that the beta-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease.

Authors:  G Perry; P L Richey; S L Siedlak; M A Smith; P Mulvihill; D A DeWitt; J Barnett; B D Greenberg; R N Kalaria
Journal:  Am J Pathol       Date:  1993-12       Impact factor: 4.307

8.  Alzheimer's disease. Beta-amyloid precursor protein expression in the nucleus basalis of Meynert.

Authors:  G M Murphy; B D Greenberg; W G Ellis; L S Forno; S M Salamat; P A Gonzalez-DeWhitt; D E Lowery; J R Tinklenberg; L F Eng
Journal:  Am J Pathol       Date:  1992-08       Impact factor: 4.307

9.  Relationship of amyloid beta/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia.

Authors:  C Schwab; J C Steele; H Akiyama; E G McGeer; P L McGeer
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

10.  Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases.

Authors:  P R Hof; C Bouras; L Buée; A Delacourte; D P Perl; J H Morrison
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088
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