Literature DB >> 19820828

Preparation and antitubercular activity of lipophilic diamines and amino alcohols.

Celso O R Júnior1, Mireille le Hyaric, Cristiane F da Costa, Taís A Corrêa, Aline F Taveira, Débora P Araújo, Elaine F C Reis, Maria Cristina S Lourenço, Felipe R C Vicente, Mauro V de Almeida.   

Abstract

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.

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Year:  2009        PMID： 19820828     DOI： 10.1590/s0074-02762009000500006

Source DB:  PubMed          Journal:  Mem Inst Oswaldo Cruz        ISSN： 0074-0276            Impact factor:   2.743


  3 in total

Review 1.  Biological potential of thiazolidinedione derivatives of synthetic origin.

Authors:  Sumit Tahlan; Prabhakar Kumar Verma
Journal:  Chem Cent J       Date:  2017-12-08       Impact factor: 4.215

2.  In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis.

Authors:  César Augusto Caneschi; Angelina Maria de Almeida; Francislene Juliana Martins; Mireille Le Hyaric; Manoel Marques Evangelista Oliveira; Gilson Costa Macedo; Mauro Vieira de Almeida; Nádia Rezende Barbosa Raposo
Journal:  Braz J Microbiol       Date:  2017-02-09       Impact factor: 2.476

3.  The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms.

Authors:  Policarpo Ademar Sales Júnior; Celso Oliveira Rezende Júnior; Mireille Le Hyaric; Mauro Vieira de Almeida; Alvaro José Romanha
Journal:  Mem Inst Oswaldo Cruz       Date:  2014-04-25       Impact factor: 2.743
  3 in total

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