Literature DB >> 19819720

The hinge region: an important receptor component for GPHR function.

Sandra Mueller1, Holger Jaeschke, Robert Günther, Ralf Paschke.   

Abstract

Glycoprotein hormone receptors (GPHRs) are members of the seven-transmembrane-spanning receptor family characterized by a large ectodomain. The hinge region belongs to a part of the GPHR ectodomain for which the three-dimensional structure has not yet been deciphered, leaving important questions unanswered concerning ligand binding and GPHR activation. Recent publications indicate that specific residues of the hinge region mediate hormone binding, receptor activation and/or intramolecular signaling for the three GPHRs, emphasizing the importance of this region. Based on these findings, the hinge region is involved at least in part in hormone binding and receptor activation. This review summarizes functional data regarding the hinge region, demonstrating that this receptor portion represents a link between ligand binding and subsequent GPHR activation. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19819720     DOI： 10.1016/j.tem.2009.09.001

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  15 in total

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Journal:  J Biol Chem       Date:  2012-08-17       Impact factor: 5.157

Review 2.  Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.

Authors:  Alfredo Ulloa-Aguirre; Teresa Zariñán; James A Dias; P Michael Conn
Journal:  Mol Cell Endocrinol       Date:  2013-06-24       Impact factor: 4.102

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Authors:  Xuliang Jiang; Heli Liu; Xiaoyan Chen; Po-Han Chen; David Fischer; Venkataraman Sriraman; Henry N Yu; Steve Arkinstall; Xiaolin He
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-16       Impact factor: 11.205

Review 4.  Structure, function and regulation of gonadotropin receptors - a perspective.

Authors:  K M J Menon; Bindu Menon
Journal:  Mol Cell Endocrinol       Date:  2012-02-09       Impact factor: 4.102

5.  Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological function.

Authors:  Sepehr Hamidi; Chun-Rong Chen; Yumiko Mizutori-Sasai; Sandra M McLachlan; Basil Rapoport
Journal:  Mol Endocrinol       Date:  2010-11-24

6.  Trafficking of the follitropin receptor.

Authors:  Alfredo Ulloa-Aguirre; James A Dias; George Bousfield; Ilpo Huhtaniemi; Eric Reiter
Journal:  Methods Enzymol       Date:  2013       Impact factor: 1.600

7.  Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation.

Authors:  Joerg Schaarschmidt; Marcus B M Nagel; Sandra Huth; Holger Jaeschke; Rocco Moretti; Vera Hintze; Martin von Bergen; Stefan Kalkhof; Jens Meiler; Ralf Paschke
Journal:  J Biol Chem       Date:  2016-04-26       Impact factor: 5.157

Review 8.  Graves' Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies.

Authors:  S A Morshed; T F Davies
Journal:  Horm Metab Res       Date:  2015-09-11       Impact factor: 2.936

9.  The role of thyrotrophin receptor antibody assays in graves' disease.

Authors:  C Kamath; M A Adlan; L D Premawardhana
Journal:  J Thyroid Res       Date:  2012-04-19

10.  The hinge region of human thyroid-stimulating hormone (TSH) receptor operates as a tunable switch between hormone binding and receptor activation.

Authors:  Ritankar Majumdar; Rajan R Dighe
Journal:  PLoS One       Date:  2012-07-06       Impact factor: 3.240
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