Literature DB >> 19819696

Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin.

Mankil Jung1, Namsoo Park, Hyung-In Moon, Yongnam Lee, Won-Yoon Chung, Kwang-Kyun Park.   

Abstract

Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.

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Year:  2009        PMID: 19819696     DOI: 10.1016/j.bmcl.2009.09.093

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

Review 1.  Development of artemisinin compounds for cancer treatment.

Authors:  Henry C Lai; Narendra P Singh; Tomikazu Sasaki
Journal:  Invest New Drugs       Date:  2012-08-31       Impact factor: 3.850

  1 in total

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