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Literature DB >> 19819582

Sex determination: the power of DMRT1.

Abstract

DMRT1, a mammalian gene related to sex-determining genes in flies and nematodes, is located in a region of the human genome that is important for sex development. This suggests that a common thread might run through the evolution of sex-determining mechanisms from worms to humans. New data show that DMRT1 can cause sex reversal in chickens, adding support to this hypothesis.

Entities: Gene Species

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Year: 2009 PMID： 19819582 DOI： 10.1016/j.tig.2009.09.009

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

9 in total

1. A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.

Authors: Peter A Kanetsky; Nandita Mitra; Saran Vardhanabhuti; David J Vaughn; Mingyao Li; Stephanie L Ciosek; Richard Letrero; Kurt D'Andrea; Madhavi Vaddi; David R Doody; Joellen Weaver; Chu Chen; Jacqueline R Starr; Håkon Håkonarson; Daniel J Rader; Andrew K Godwin; Muredach P Reilly; Stephen M Schwartz; Katherine L Nathanson
Journal: Hum Mol Genet Date: 2011-05-06 Impact factor: 6.150

2. Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.

Authors: N L Manuylov; B Zhou; Q Ma; S C Fox; W T Pu; S G Tevosian
Journal: Dev Biol Date: 2011-03-06 Impact factor: 3.582

3. A Wt1-Dmrt1 transgene restores DMRT1 to sertoli cells of Dmrt1(-/-) testes: a novel model of DMRT1-deficient germ cells.

Authors: Valentine A Agbor; Shixin Tao; Ning Lei; Leslie L Heckert
Journal: Biol Reprod Date: 2013-02-01 Impact factor: 4.285

4. Pathway-based analysis of GWAs data identifies association of sex determination genes with susceptibility to testicular germ cell tumors.

Authors: Roelof Koster; Nandita Mitra; Kurt D'Andrea; Saran Vardhanabhuti; Charles C Chung; Zhaoming Wang; R Loren Erickson; David J Vaughn; Kevin Litchfield; Nazneen Rahman; Mark H Greene; Katherine A McGlynn; Clare Turnbull; Stephen J Chanock; Katherine L Nathanson; Peter A Kanetsky
Journal: Hum Mol Genet Date: 2014-06-18 Impact factor: 6.150

Sex determination: the power of DMRT1.

1. A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.

2. Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.

3. A Wt1-Dmrt1 transgene restores DMRT1 to sertoli cells of Dmrt1(-/-) testes: a novel model of DMRT1-deficient germ cells.

4. Pathway-based analysis of GWAs data identifies association of sex determination genes with susceptibility to testicular germ cell tumors.

Review 5. Genetic architecture of sex determination in fish: applications to sex ratio control in aquaculture.

6. A high-density genetic linkage map and QTL mapping for growth and sex of yellow drum (Nibea albiflora).

7. Dmrt1 regulates the immune response by repressing the TLR4 signaling pathway in goat male germline stem cells.

8. Loss of dmrt1 restores zebrafish female fates in the absence of cyp19a1a but not rbpms2a/b.

Review 9. Genetic Regulation of Avian Testis Development.