BACKGROUND: A genetic contribution to smoking behavior is well-established. To identify loci that increase the risk for smoking behavior, many genome-wide linkage scans have been performed with various smoking behavior assessments. Numerous putative susceptibility loci have been identified, but only a few of these were replicated in independent studies. METHODS: We used genome search meta-analysis (GSMA) to identify risk loci by pooling all available independent genome scan results on smoking behavior. Additionally, to minimize locus heterogeneity, subgroup analyses of the smoking behavior assessed by the Fagerstrom Test for Nicotine Dependence (FTND) and maximum number of cigarettes smoked in a 24-hour period (MaxCigs24) were carried out. Samples of European ancestry were also analyzed separately. RESULTS: A total number of 15 genome scan results were available for analysis, including 3404 families with 10,253 subjects. Overall, the primary GSMA across all smoking behavior identified a genome-wide suggestive linkage in chromosome 17q24.3-q25.3 (p(SR) = .001). A secondary analysis of FTND in European-ancestry samples (625 families with 1878 subjects) detected a genome-wide suggestive linkage in 5q33.1-5q35.2 (p(SR) = .0076). Subgroup analysis of MaxCigs24 (966 families with 3273 subjects) identified a genome-wide significant linkage in 20q13.12-q13.32 (p(SR) = .00041, p(OR) = .048), where a strongly supported nicotine dependence candidate gene, CHRNA4, is located. CONCLUSIONS: The regions identified in the current study deserve close attention and will be helpful for candidate gene identification or target re-sequencing studies in the future.
BACKGROUND: A genetic contribution to smoking behavior is well-established. To identify loci that increase the risk for smoking behavior, many genome-wide linkage scans have been performed with various smoking behavior assessments. Numerous putative susceptibility loci have been identified, but only a few of these were replicated in independent studies. METHODS: We used genome search meta-analysis (GSMA) to identify risk loci by pooling all available independent genome scan results on smoking behavior. Additionally, to minimize locus heterogeneity, subgroup analyses of the smoking behavior assessed by the Fagerstrom Test for Nicotine Dependence (FTND) and maximum number of cigarettes smoked in a 24-hour period (MaxCigs24) were carried out. Samples of European ancestry were also analyzed separately. RESULTS: A total number of 15 genome scan results were available for analysis, including 3404 families with 10,253 subjects. Overall, the primary GSMA across all smoking behavior identified a genome-wide suggestive linkage in chromosome 17q24.3-q25.3 (p(SR) = .001). A secondary analysis of FTND in European-ancestry samples (625 families with 1878 subjects) detected a genome-wide suggestive linkage in 5q33.1-5q35.2 (p(SR) = .0076). Subgroup analysis of MaxCigs24 (966 families with 3273 subjects) identified a genome-wide significant linkage in 20q13.12-q13.32 (p(SR) = .00041, p(OR) = .048), where a strongly supported nicotine dependence candidate gene, CHRNA4, is located. CONCLUSIONS: The regions identified in the current study deserve close attention and will be helpful for candidate gene identification or target re-sequencing studies in the future.
Authors: Laura Jean Bierut; John P Rice; Alison Goate; Anthony L Hinrichs; Nancy L Saccone; Tatiana Foroud; Howard J Edenberg; C Robert Cloninger; Henri Begleiter; P Michael Conneally; Raymond R Crowe; Victor Hesselbrock; Ting-Kai Li; John I Nurnberger; Bernice Porjesz; Marc A Schuckit; Theodore Reich Journal: Am J Med Genet A Date: 2004-01-01 Impact factor: 2.802
Authors: Gary E Swan; Hyman Hops; Kirk C Wilhelmsen; Christina N Lessov-Schlaggar; Li S-C Cheng; Karen S Hudmon; Christopher I Amos; Heidi S Feiler; Huijun Z Ring; Judy A Andrews; Elizabeth Tildesley; Neal Benowitz Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2006-06-05 Impact factor: 3.568
Authors: Kent E Hutchison; David L Allen; Francesca M Filbey; Christopher Jepson; Caryn Lerman; Neal L Benowitz; Jerry Stitzel; Angela Bryan; John McGeary; Heather M Haughey Journal: Arch Gen Psychiatry Date: 2007-09
Authors: Y-Z Liu; Y-F Pei; Y-F Guo; L Wang; X-G Liu; H Yan; D-H Xiong; Y-P Zhang; S Levy; J Li; C K Haddock; C J Papasian; Q Xu; J Z Ma; T J Payne; R R Recker; M D Li; H-W Deng Journal: Mol Psychiatry Date: 2009-02-03 Impact factor: 15.992
Authors: Hreinn Stefansson; Dan Rujescu; Sven Cichon; Olli P H Pietiläinen; Andres Ingason; Stacy Steinberg; Ragnheidur Fossdal; Engilbert Sigurdsson; Thordur Sigmundsson; Jacobine E Buizer-Voskamp; Thomas Hansen; Klaus D Jakobsen; Pierandrea Muglia; Clyde Francks; Paul M Matthews; Arnaldur Gylfason; Bjarni V Halldorsson; Daniel Gudbjartsson; Thorgeir E Thorgeirsson; Asgeir Sigurdsson; Adalbjorg Jonasdottir; Aslaug Jonasdottir; Asgeir Bjornsson; Sigurborg Mattiasdottir; Thorarinn Blondal; Magnus Haraldsson; Brynja B Magnusdottir; Ina Giegling; Hans-Jürgen Möller; Annette Hartmann; Kevin V Shianna; Dongliang Ge; Anna C Need; Caroline Crombie; Gillian Fraser; Nicholas Walker; Jouko Lonnqvist; Jaana Suvisaari; Annamarie Tuulio-Henriksson; Tiina Paunio; Timi Toulopoulou; Elvira Bramon; Marta Di Forti; Robin Murray; Mirella Ruggeri; Evangelos Vassos; Sarah Tosato; Muriel Walshe; Tao Li; Catalina Vasilescu; Thomas W Mühleisen; August G Wang; Henrik Ullum; Srdjan Djurovic; Ingrid Melle; Jes Olesen; Lambertus A Kiemeney; Barbara Franke; Chiara Sabatti; Nelson B Freimer; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Ole A Andreassen; Roel A Ophoff; Alexander Georgi; Marcella Rietschel; Thomas Werge; Hannes Petursson; David B Goldstein; Markus M Nöthen; Leena Peltonen; David A Collier; David St Clair; Kari Stefansson Journal: Nature Date: 2008-09-11 Impact factor: 49.962
Authors: Andrew W Bergen; Harold S Javitz; Ruth Krasnow; Martha Michel; Denise Nishita; David V Conti; Christopher K Edlund; Pui-Yan Kwok; Jennifer B McClure; Richard B Kim; Sharon M Hall; Rachel F Tyndale; Timothy B Baker; Neal L Benowitz; Gary E Swan Journal: Nicotine Tob Res Date: 2014-08-20 Impact factor: 4.244
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