| Literature DB >> 19819138 |
Janeta Popovici-Muller1, Gerald W Shipps, Kristin E Rosner, Yongqi Deng, Tong Wang, Patrick J Curran, Meredith A Brown, M Arshad Siddiqui, Alan B Cooper, José Duca, Michael Cable, Viyyoor Girijavallabhan.
Abstract
The present paper describes a novel series of HCV RNA polymerase inhibitors based on a pyrazolo[1,5-a]pyrimidine scaffold bearing hydrophobic groups and an acidic functionality. Several compounds were optimized to low nanomolar potencies in a biochemical RdRp assay. SAR trends clearly reveal a stringent preference for a cyclohexyl group as one of the hydrophobes, and improved activities for carboxylic acid derivatives.Entities:
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Year: 2009 PMID： 19819138 DOI： 10.1016/j.bmcl.2009.09.087
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823